TY - GEN ID - cogprints5763 UR - http://cogprints.org/5763/ A1 - Abbott, P. A1 - Thompson, A. C. A1 - Ferguson, E.J. A1 - Doerr, J. C. A1 - Tarapacki, J. A. A1 - Kostyniak, Dr. P.J. A1 - Syracuse, J.A. A1 - Cartonia, D.M. A1 - Kristal, Dr. Mark B. Y1 - 1991/// N2 - A substance in amniotic fluid and placenta (POEF for Placental Opioid-Enhancing Factor) has been shown to enhance opiate- or opioid-mediated analgesia in rats. Recent studies have only touched on the generalizability of the phenomenon. The present studies further tested the generalizability of the POEF effect: they examined sex specificity of the mechanism, whether POEF activity exists in afterbirth material of species other than the rat; whether POEF activity exists in tissue other than afterbirth material; whether POEF activity could be demonstrated after injection rather than ingestion of afterbirth material; and whether POEF enhances all opioid-mediated phenomena. We found that (a) POEF is effective in male rats as well as in female rats; (b) POEF activity exists in human and dolphin afterbirth material; (c) ingestion of pregnant-rat liver does not produce enhancement of opioid-mediated analgesia; (d) POEF does not seem to be effective when amniotic fluid is injected either IPO or SC; and (e) POEF does not modify morphine-induced hyperthermia. PB - Pergamon Press KW - POEF KW - placenta KW - analgesia KW - opioids KW - amniotic fluid KW - pain KW - morphine KW - birth KW - placentophagia TI - Placental opioid-enhancing factor (POEF): Generalizability of effects SP - 933 AV - public EP - 940 ER -