<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "Placental opioid-enhancing factor (POEF): Generalizability of effects"^^ . "A substance in amniotic fluid and placenta (POEF for Placental Opioid-Enhancing Factor) has been shown to enhance opiate- or opioid-mediated analgesia in rats. Recent studies have only touched on the generalizability of the phenomenon. The present studies further tested the generalizability of the POEF effect: they examined sex specificity of the mechanism, whether POEF activity exists in afterbirth material of species other than the rat; whether POEF activity exists in tissue other than afterbirth material; whether POEF activity could be demonstrated after injection rather than ingestion of afterbirth material; and whether POEF enhances all opioid-mediated phenomena. We found that (a) POEF is effective in male rats as well as in female rats; (b) POEF activity exists in human and dolphin afterbirth material; (c) ingestion of pregnant-rat liver does not produce enhancement of opioid-mediated analgesia; (d) POEF does not seem to be effective when amniotic fluid is injected either IPO or SC; and (e) POEF does not modify morphine-induced hyperthermia."^^ . "1991" . . "50" . "5" . . "Pergamon Press"^^ . . . "Physiology & Behavior"^^ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Mark B."^^ . "Kristal"^^ . "Mark B. Kristal"^^ . . "J. C."^^ . "Doerr"^^ . "J. C. Doerr"^^ . . "A. C."^^ . "Thompson"^^ . "A. C. Thompson"^^ . . "P."^^ . "Abbott"^^ . "P. Abbott"^^ . . "J. A."^^ . "Tarapacki"^^ . "J. A. Tarapacki"^^ . . "J.A."^^ . "Syracuse"^^ . "J.A. Syracuse"^^ . . "P.J."^^ . "Kostyniak"^^ . "P.J. Kostyniak"^^ . . "E.J."^^ . "Ferguson"^^ . "E.J. Ferguson"^^ . . "D.M."^^ . "Cartonia"^^ . "D.M. Cartonia"^^ . . . . . . "Placental opioid-enhancing factor (POEF): Generalizability of effects (PDF)"^^ . . . . . . "generalize.pdf"^^ . . . "Placental opioid-enhancing factor (POEF): Generalizability of effects (Image (PNG))"^^ . . . . . . "preview.png"^^ . . "HTML Summary of #5763 \n\nPlacental opioid-enhancing factor (POEF): Generalizability of effects\n\n" . "text/html" . . . "Behavioral Neuroscience" . .