title: Placental opioid-enhancing factor (POEF): Generalizability of effects
creator: Abbott, P.
creator: Thompson, A. C.
creator: Ferguson, E.J.
creator: Doerr, J. C.
creator: Tarapacki, J. A.
creator: Kostyniak, Dr. P.J.
creator: Syracuse, J.A.
creator: Cartonia, D.M.
creator: Kristal, Dr. Mark B.
subject: Behavioral Neuroscience
description: A substance in amniotic fluid and placenta (POEF for Placental Opioid-Enhancing Factor) has been shown to enhance opiate- or opioid-mediated analgesia in rats. Recent studies have only touched on the generalizability of the phenomenon. The present studies further tested the generalizability of the POEF effect: they examined sex specificity of the mechanism, whether POEF activity exists in afterbirth material of species other than the rat; whether POEF activity exists in tissue other than afterbirth material; whether POEF activity could be demonstrated after injection rather than ingestion of afterbirth material; and whether POEF enhances all opioid-mediated phenomena. We found that (a) POEF is effective in male rats as well as in female rats; (b) POEF activity exists in human and dolphin afterbirth material; (c) ingestion of pregnant-rat liver does not produce enhancement of opioid-mediated analgesia; (d) POEF does not seem to be effective when amniotic fluid is injected either IPO or SC; and (e) POEF does not modify morphine-induced hyperthermia.
publisher: Pergamon Press
date: 1991
type: Journal (Paginated)
type: PeerReviewed
format: application/pdf
identifier: http://cogprints.org/5763/1/generalize.pdf
identifier:   Abbott, P. and Thompson, A. C. and Ferguson, E.J. and Doerr, J. C. and Tarapacki, J. A. and Kostyniak, Dr. P.J. and Syracuse, J.A. and Cartonia, D.M. and Kristal, Dr. Mark B.  (1991) Placental opioid-enhancing factor (POEF): Generalizability of effects.  [Journal (Paginated)]     
relation: http://cogprints.org/5763/