?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Placental+opioid-enhancing+factor+(POEF)%3A+Generalizability+of+effects&rft.creator=Abbott%2C+P.&rft.creator=Thompson%2C+A.+C.&rft.creator=Ferguson%2C+E.J.&rft.creator=Doerr%2C+J.+C.&rft.creator=Tarapacki%2C+J.+A.&rft.creator=Kostyniak%2C+Dr.+P.J.&rft.creator=Syracuse%2C+J.A.&rft.creator=Cartonia%2C+D.M.&rft.creator=Kristal%2C+Dr.+Mark+B.&rft.subject=Behavioral+Neuroscience&rft.description=A+substance+in+amniotic+fluid+and+placenta+(POEF+for+Placental+Opioid-Enhancing+Factor)+has+been+shown+to+enhance+opiate-+or+opioid-mediated+analgesia+in+rats.+Recent+studies+have+only+touched+on+the+generalizability+of+the+phenomenon.+The+present+studies+further+tested+the+generalizability+of+the+POEF+effect%3A+they+examined+sex+specificity+of+the+mechanism%2C+whether+POEF+activity+exists+in+afterbirth+material+of+species+other+than+the+rat%3B+whether+POEF+activity+exists+in+tissue+other+than+afterbirth+material%3B+whether+POEF+activity+could+be+demonstrated+after+injection+rather+than+ingestion+of+afterbirth+material%3B+and+whether+POEF+enhances+all+opioid-mediated+phenomena.+We+found+that+(a)+POEF+is+effective+in+male+rats+as+well+as+in+female+rats%3B+(b)+POEF+activity+exists+in+human+and+dolphin+afterbirth+material%3B+(c)+ingestion+of+pregnant-rat+liver+does+not+produce+enhancement+of+opioid-mediated+analgesia%3B+(d)+POEF+does+not+seem+to+be+effective+when+amniotic+fluid+is+injected+either+IPO+or+SC%3B+and+(e)+POEF+does+not+modify+morphine-induced+hyperthermia.&rft.publisher=Pergamon+Press&rft.date=1991&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F5763%2F1%2Fgeneralize.pdf&rft.identifier=++Abbott%2C+P.+and+Thompson%2C+A.+C.+and+Ferguson%2C+E.J.+and+Doerr%2C+J.+C.+and+Tarapacki%2C+J.+A.+and+Kostyniak%2C+Dr.+P.J.+and+Syracuse%2C+J.A.+and+Cartonia%2C+D.M.+and+Kristal%2C+Dr.+Mark+B.++(1991)+Placental+opioid-enhancing+factor+(POEF)%3A+Generalizability+of+effects.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F5763%2F