---
abstract: 'Opioids produce antinociception, and ingested placenta or amniotic fluid modifies that antinociception. More specifically, ingested placenta enhances the antinociception produced by selective activation of central n-opioid or y-opioid receptors but attenuates that produced by activation of central A-opioid receptors. Opioids also slow gut transit by acting on central or peripheral A-opioid receptors. Therefore, we hypothesized that ingested placenta would reverse the slowing of gut transit that is produced by morphine, a preferential A-opioid-receptor agonist. Rats were injected with morphine either centrally or systemically and fed placenta, after which gastrointestinal transit was evaluated. We report here that ingested placenta reversed the slowing of gut transit produced by centrally administered morphine but did not affect the slowing of gut transit produced by systemically administered morphine. These results suggest another likely consequence of placentophagia at parturition in mammals—reversal of opioid-mediated, pregnancy-based disruption of gastrointestinal function—as well as an important consideration in opioid-based treatments for pain in humans—enhancement of desirable effects with attenuation of adverse effects.'
altloc: []
chapter: ~
commentary: ~
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contact_email: ~
creators_id:
  - ''
  - ''
  - kristal@buffalo.edu
creators_name:
  - family: Corpening
    given: James W.
    honourific: Dr.
    lineage: ''
  - family: Doerr
    given: Jean C.
    honourific: Dr.
    lineage: ''
  - family: Kristal
    given: Mark B.
    honourific: Dr.
    lineage: ''
date: 2004
date_type: published
datestamp: 2007-09-28 23:22:25
department: ~
dir: disk0/00/00/57/28
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editors_id: []
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eprint_status: archive
eprintid: 5728
fileinfo: /style/images/fileicons/application_pdf.png;/5728/1/Corpening.pdf
full_text_status: public
importid: ~
institution: ~
isbn: ~
ispublished: pub
issn: ~
item_issues_comment: []
item_issues_count: 0
item_issues_description: []
item_issues_id: []
item_issues_reported_by: []
item_issues_resolved_by: []
item_issues_status: []
item_issues_timestamp: []
item_issues_type: []
keywords: 'placenta, gut, POEF, analgesia, placentophagia, rat'
lastmod: 2011-03-11 08:56:58
latitude: ~
longitude: ~
metadata_visibility: show
note: ~
number: ~
pagerange: 217-221
pubdom: FALSE
publication: Brain Research
publisher: Elsevier
refereed: TRUE
referencetext: ~
relation_type: []
relation_uri: []
reportno: ~
rev_number: 21
series: ~
source: ~
status_changed: 2007-09-28 23:22:25
subjects:
  - behav-neuro-sci
succeeds: ~
suggestions: ~
sword_depositor: ~
sword_slug: ~
thesistype: ~
title: Ingested placenta blocks the effect of morphine on gut transit in Long–Evans rats
type: journalp
userid: 88
volume: 1016
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