---
abstract: "The analgesic effect of orally administered buprenorphine was compared with that induced by a standard\r\ntherapeutic injected dose (0.05 mg/kg of body weight, s.c.) in male Long-Evans rats. Analgesia was assessed by\r\nmeasuring pain threshold, using the hot-water tail-flick assay before and after administration of buprenorphine.\r\nThe results suggest that a commonly used formula for oral buprenorphine in flavored gelatin, at a dose of 0.5\r\nmg/kg, does not increase pain threshold in rats. Instead, oral buprenorphine doses of 5 and 10 mg/kg were\r\nnecessary to induce significant increases in pain threshold. However, these doses had to be administered by\r\norogastric infusion because the rats would not voluntarily eat flavored gelatin containing this much buprenorphine.\r\nThe depth of analgesia induced by these infused doses was comparable to that induced by the clinically effective\r\ns.c. treatment (0.05 mg/kg)."
altloc: []
chapter: ~
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contact_email: ~
creators_id:
  - ''
  - ''
  - ''
  - kristal@buffalo.edu
creators_name:
  - family: Martin
    given: Lisa B.E.
    honourific: Dr.
    lineage: ''
  - family: Thompson
    given: Alexis C.
    honourific: Dr.
    lineage: ''
  - family: Martin
    given: Thomas
    honourific: Dr.
    lineage: ''
  - family: Kristal
    given: Mark B.
    honourific: Dr.
    lineage: ''
date: 2001-02
date_type: published
datestamp: 2007-09-28 23:23:12
department: ~
dir: disk0/00/00/57/22
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editors_id: []
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eprint_status: archive
eprintid: 5722
fileinfo: /style/images/fileicons/application_pdf.png;/5722/1/buprenorphine.pdf
full_text_status: public
importid: ~
institution: ~
isbn: ~
ispublished: pub
issn: ~
item_issues_comment: []
item_issues_count: 0
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item_issues_status: []
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item_issues_type: []
keywords: 'buprenorphine, analgesia, pain, rat'
lastmod: 2011-03-11 08:56:58
latitude: ~
longitude: ~
metadata_visibility: show
note: ~
number: 1
pagerange: 43-48
pubdom: TRUE
publication: Comparative Medicine
publisher: American Association for Laboratory Animal Science
refereed: TRUE
referencetext: ~
relation_type: []
relation_uri: []
reportno: ~
rev_number: 23
series: ~
source: ~
status_changed: 2007-09-28 23:23:12
subjects:
  - behav-neuro-sci
succeeds: ~
suggestions: ~
sword_depositor: ~
sword_slug: ~
thesistype: ~
title: "Analgesic Efficacy of Orally Administered\r\nBuprenorphine in Rats"
type: journalp
userid: 88
volume: 51
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