creators_name: Martin, Lisa B.E.
creators_name: Thompson, Alexis C.
creators_name: Martin, Thomas
creators_name: Kristal, Mark B.
creators_id: 
creators_id: 
creators_id: 
creators_id: kristal@buffalo.edu
type: journalp
datestamp: 2007-09-28 23:23:12
lastmod: 2011-03-11 08:56:58
metadata_visibility: show
title: Analgesic Efficacy of Orally Administered
Buprenorphine in Rats
ispublished: pub
subjects: behav-neuro-sci
full_text_status: public
keywords: buprenorphine, analgesia, pain, rat
abstract: The analgesic effect of orally administered buprenorphine was compared with that induced by a standard
therapeutic injected dose (0.05 mg/kg of body weight, s.c.) in male Long-Evans rats. Analgesia was assessed by
measuring pain threshold, using the hot-water tail-flick assay before and after administration of buprenorphine.
The results suggest that a commonly used formula for oral buprenorphine in flavored gelatin, at a dose of 0.5
mg/kg, does not increase pain threshold in rats. Instead, oral buprenorphine doses of 5 and 10 mg/kg were
necessary to induce significant increases in pain threshold. However, these doses had to be administered by
orogastric infusion because the rats would not voluntarily eat flavored gelatin containing this much buprenorphine.
The depth of analgesia induced by these infused doses was comparable to that induced by the clinically effective
s.c. treatment (0.05 mg/kg).
date: 2001-02
date_type: published
publication: Comparative Medicine
volume: 51
number: 1
publisher: American Association for Laboratory Animal Science
pagerange: 43-48
refereed: TRUE
citation:   Martin, Dr. Lisa B.E. and Thompson, Dr. Alexis C. and Martin, Dr. Thomas and Kristal, Dr. Mark B.  (2001) Analgesic Efficacy of Orally Administered Buprenorphine in Rats.  [Journal (Paginated)]     
document_url: http://cogprints.org/5722/1/buprenorphine.pdf