?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Analgesic+Efficacy+of+Orally+Administered%0D%0ABuprenorphine+in+Rats&rft.creator=Martin%2C+Dr.+Lisa+B.E.&rft.creator=Thompson%2C+Dr.+Alexis+C.&rft.creator=Martin%2C+Dr.+Thomas&rft.creator=Kristal%2C+Dr.+Mark+B.&rft.subject=Behavioral+Neuroscience&rft.description=The+analgesic+effect+of+orally+administered+buprenorphine+was+compared+with+that+induced+by+a+standard%0D%0Atherapeutic+injected+dose+(0.05+mg%2Fkg+of+body+weight%2C+s.c.)+in+male+Long-Evans+rats.+Analgesia+was+assessed+by%0D%0Ameasuring+pain+threshold%2C+using+the+hot-water+tail-flick+assay+before+and+after+administration+of+buprenorphine.%0D%0AThe+results+suggest+that+a+commonly+used+formula+for+oral+buprenorphine+in+flavored+gelatin%2C+at+a+dose+of+0.5%0D%0Amg%2Fkg%2C+does+not+increase+pain+threshold+in+rats.+Instead%2C+oral+buprenorphine+doses+of+5+and+10+mg%2Fkg+were%0D%0Anecessary+to+induce+significant+increases+in+pain+threshold.+However%2C+these+doses+had+to+be+administered+by%0D%0Aorogastric+infusion+because+the+rats+would+not+voluntarily+eat+flavored+gelatin+containing+this+much+buprenorphine.%0D%0AThe+depth+of+analgesia+induced+by+these+infused+doses+was+comparable+to+that+induced+by+the+clinically+effective%0D%0As.c.+treatment+(0.05+mg%2Fkg).&rft.publisher=American+Association+for+Laboratory+Animal+Science&rft.date=2001-02&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F5722%2F1%2Fbuprenorphine.pdf&rft.identifier=++Martin%2C+Dr.+Lisa+B.E.+and+Thompson%2C+Dr.+Alexis+C.+and+Martin%2C+Dr.+Thomas+and+Kristal%2C+Dr.+Mark+B.++(2001)+Analgesic+Efficacy+of+Orally+Administered+Buprenorphine+in+Rats.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F5722%2F