@misc{cogprints5653,
          volume = {390},
          number = {3},
           month = {March},
          author = {Eduardo Candelario-Jalil and Hussam Ajamieh and Susana Sam and Gregorio Martinez and Olga S. Leon},
           title = {Nimesulide limits kainate-induced oxidative damage in the rat hippocampus},
       publisher = {Elsevier},
            year = {2000},
         journal = {European Journal of Pharmacology},
           pages = {295--298},
        keywords = {kainate; excitotoxicity; cyclooxygenase-2; nimesulide; oxidative stress; hippocampus},
             url = {http://cogprints.org/5653/},
        abstract = {Kainate induces a marked expression of cyclooxygenase-2 after its systemic administration. Because cyclooxygenase-2 activity is associated to the production of reactive oxygen species, we investigated the effects of nimesulide, a selective cyclooxygenase-2 inhibitor, on kainate-induced in vivo oxidative damage in the rat hippocampus. A clinically relevant dose of nimesulide (6 mg/kg, i.p. ) was administered three times following kainate application (9 mg/kg, i.p.). After 24 h of kainate administration, the drastic decrease in hippocampal glutathione content and the significant increase in lipid peroxidation were attenuated in nimesulide-treated rats, suggesting that the induction of cyclooxygenase-2 is involved in kainate-mediated free radicals formation.}
}

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