?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Time+course+of+oxidative+damage+in+different+brain+regions+following+transient+cerebral+ischemia+in+gerbils&rft.creator=Candelario-Jalil%2C+Eduardo&rft.creator=Mhadu%2C+Noel+H.&rft.creator=Al-Dalain%2C+Saied+M.&rft.creator=Martinez%2C+Gregorio&rft.creator=Leon%2C+Olga+S.&rft.subject=Neurochemistry&rft.description=The+time+course+of+oxidative+damage+in+different+brain+regions+was+investigated+in+the+gerbil+model+of+transient+cerebral+ischemia.+Animals+were+subjected+to+both+common+carotid+arteries+occlusion+for+5+min.+After+the+end+of+ischemia+and+at+different+reperfusion+times+(2%2C+6%2C+12%2C+24%2C+48%2C+72%2C+96+h+and+7+days)%2C+markers+of+lipid+peroxidation%2C+reduced+and+oxidized+glutathione+levels%2C+glutathione+peroxidase%2C+glutathione+reductase%2C+manganese-dependent+superoxide+dismutase+(MnSOD)+and+copper%2Fzinc+containing+SOD+(Cu%2FZnSOD)+activities+were+measured+in+hippocampus%2C+cortex+and+striatum.+Oxidative+damage+in+hippocampus+was+maximal+at+late+stages+after+ischemia+(48-96+h)+coincident+with+a+significant+impairment+in+glutathione+homeostasis.+MnSOD+increased+in+hippocampus+at+24%2C+48+and+72+h+after+ischemia%2C+coincident+with+the+marked+reduction+in+the+activity+of+glutathione-related+enzymes.+The+late+disturbance+in+oxidant-antioxidant+balance+corresponds+with+the+time+course+of+delayed+neuronal+loss+in+the+hippocampal+CA1+sector.+Cerebral+cortex+showed+early+changes+in+oxidative+damage+with+no+significant+impairment+in+antioxidant+capacity.+Striatal+lipid+peroxidation+significantly+increased+as+early+as+2+h+after+ischemia+and+persisted+until+48+h+with+respect+to+the+sham-operated+group.+These+results+contribute+significant+information+on+the+timing+and+factors+that+influence+free+radical+formation+following+ischemic+brain+injury%2C+an+essential+step+in+determining+effective+antioxidant+intervention.&rft.publisher=Elsevier&rft.date=2001-11&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F5644%2F1%2FNeurosci_Res_2001_Candelario-Jalil_et_al.pdf&rft.identifier=++Candelario-Jalil%2C+Eduardo+and+Mhadu%2C+Noel+H.+and+Al-Dalain%2C+Saied+M.+and+Martinez%2C+Gregorio+and+Leon%2C+Olga+S.++(2001)+Time+course+of+oxidative+damage+in+different+brain+regions+following+transient+cerebral+ischemia+in+gerbils.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F5644%2F