?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Phencyclidine+and+(%2B)-MK-801-induced+circling+preference%3A+correlation+with+monoamine+levels+in+striatum+of+the+rat+brain&rft.creator=Ali%2C+SF&rft.creator=Newport%2C+GD&rft.creator=Bracha%2C+HS&rft.subject=Internet+Health&rft.description=Phencyclidine+(PCP%3B+angel+dust)+is+a+drug+of+abuse+known+to+produce+a+behavioral+state+in+humans+resembling+schizophrenia%2Fpsychosis.+PCP+is+a+noncompetitive+NMDA+receptor+antagonist+and+produces+a+variety+of+behaviors+in+rats+including+circling.+The+behavioral+effects+of+other+noncompetitive+NMDA+receptor+antagonists+such+as+(%2B)-MK-801+are+still+being+elucidated.+Here%2C+adult+female+rats+were+dosed+with+PCP+(10+mg%2Fkg%2C+IP)%2C+or+(%2B)-MK-801+(0.1+mg%2Fkg%2C+IP)+and+circling+preference+was+recorded+for+2+h+before+sacrifice+to+determine+monoamine+levels+by+HPLC%2FEC.+Animals+injected+with+PCP+or+(%2B)-MK-801+showed+a+preference+to+turn+to+the+left+(65%25+and+72%25%2C+respectively).+PCP+and+(%2B)-MK-801+also+produced+a+significant+increase+of+3%2C4-dihydroxyphenylacetic+acid+(DOPAC)+and+homovanillic+acid+(HVA)+in+whole+striatum+on+both+sides+of+the+brain.+Further+dissection+of+the+striatum+into+medioventral+and+dorsolateral+regions+revealed+that+HVA+was+increased+bilaterally+except+in+globus+pallidus+where+we+found+significant+increases+in+dopamine+(DA)%2C+DOPAC%2C+and+HVA+only+on+the+left+side+after+PCP+and+(%2B)-MK-801+administration.+These+data+suggest+that+PCP+and+(%2B)-MK-801+produce+a+greater+preference+to+turn+left+than+right%2C+a+finding+similar+to+that+found+in+human+psychosis.+Furthermore%2C+it+is+possible+that+this+preference+to+turn+toward+the+left+hemispace+is+due+to+an+asymmetry+in+dopamine+function+found+in+the+globus+pallidus+after+administration+of+PCP+and+similar+drugs.%0A&rft.date=1994&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F5301%2F1%2F1994_NMDA_antagonist_%2528PCP_Phencyclidine%252C_%2528%252B%2529-MK-801%2529_induced_circling_behavior.PDF&rft.identifier=++Ali%2C+SF+and+Newport%2C+GD+and+Bracha%2C+HS++(1994)+Phencyclidine+and+(%2B)-MK-801-induced+circling+preference%3A+correlation+with+monoamine+levels+in+striatum+of+the+rat+brain.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F5301%2F