?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Single-chamber+Versus+Dual-chamber+Implantable+Cardioverter+Defibrillators%3A+Do+We+Need+Physiologic+Pacing+in+The+Course%3F%0A&rft.creator=Budeus%2C+Marco&rft.creator=Buck%2C+Thomas&rft.creator=Wieneke%2C+Heinrich&rft.creator=Erbel%2C+Raimund&rft.creator=Sack%2C+Stefan&rft.subject=Indian+Pacing+and+Electrophysiology+Journal&rft.description=Background%3A+Many+patients+with+ICD+receive+different+antiarrhythmic+drugs+(e.g.+sotalol%2C+amiodarone%2C+%CE%B2-blockers)+because+of+ventricular+or+atrial+tachycardias.+These+drugs+can+cause+AV-block+or+chronotropic+incompetence+resulting+in+a+higher+percentage+of+ventricular+pacing.%0A%0AMethods%3A+We+analyzed+in+a+retrospective+study+the+impact+of+DDD(R)+versus+VVI(R)+mode+on+subjective+(NYHA+classification)+and+objective+parameters+%5Bbrain+natriuretic+peptide+(BNP)%2C+6+minute+walk+test%2C+echocardiography%5D+in+12+of+120+patients+(age+60.2+%C2%B1+11.2+years%3B+10+males%2C+2+females)+who+needed+an+upgrading+of+a+single+to+a+dual+chamber+ICD.+The+ICD+had+to+be+upgraded+because+of+chronotropic+incompetence+in+all+patients+with+signs+of+progressing+heart+failure.+Data+were+collected+in+VVI(R)-pacing+and+after+6+and+12+months+in+DDD(R)-pacing+with+a+long+AV-interval+and+AV+hysteresis+to+reduce+ventricular+pacing.%0A%0AResults%3A+The+6+minute+walk+test+(392.4+%C2%B1+91.4+vs.+324.6+%C2%B1+93.3+m%2C+P+%3C+0.001)%2C+NYHA-classification+(1.4+%C2%B1+0.3+vs.+2.6+%C2%B1+0.8%2C+P+%3C+0.0001)%2C+BNP+(234.1+%C2%B1+73.5+vs.+410.4+%C2%B1+297.0+pg%2Fml%2C+P+%3C+0.001)%2C+left+ventricular+ejection+fraction+(49.8+%C2%B1+9.6+vs.+36.5+%C2%B1+10.9+%25%2C+P+%3C+0.0001)+and+A-wave+(73.6+%C2%B1+13.7+vs.+41.0+%C2%B1+14.0+cm%2Fsec%2C+P+%3C+0.0001)+improved+with+DDD(R)-pacing+after+12+months.+The+ventricular+pacing+decreased+(84.2+%C2%B1+18.1+vs.+1.1+%C2%B1+1.7+%25%2C+P+%3C+0.0001)+after+12+months+by+DDD(R)-pacing+with+long+AV-interval+(220.0+%C2%B1+10.4+ms)+and+AV+hysteresis.%0A%0AConclusion%3A+Our+data+show+a+superiority+of+DDD(R)+mode+versus+VVI(R)+mode+regarding+subjective+and+objective+parameters+as+NYHA-classification%2C+BNP%2C+6+minute+walk+test%2C+left+ventricular+ejection+fraction+and+left+ventricular+endsystolic+volume+after+12+months.+The+improvements+seem+to+depend+on+the+reduction+of+ventricular+pacing+with+advanced+atrial+contraction.+But+only+a+small+number+of+patients+needed+the+upgradation.+%0A&rft.publisher=Indian+Pacing+and+Electrophysiology+Group&rft.contributor=Singh%2C+Balbir&rft.contributor=Lokhandwala%2C+Yash&rft.contributor=Francis%2C+Johnson&rft.contributor=Gupta%2C+Anup&rft.contributor=Ghosh%2C+Joydeep&rft.date=2006-07&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=text%2Fhtml&rft.identifier=http%3A%2F%2Fcogprints.org%2F5211%2F1%2Fbudeus.htm&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F5211%2F2%2Fbudeus.pdf&rft.identifier=++Budeus%2C+Marco+and+Buck%2C+Thomas+and+Wieneke%2C+Heinrich+and+Erbel%2C+Raimund+and+Sack%2C+Stefan++(2006)+Single-chamber+Versus+Dual-chamber+Implantable+Cardioverter+Defibrillators%3A+Do+We+Need+Physiologic+Pacing+in+The+Course%3F++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F5211%2F