?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Changes+in+Striatal+N-methyl-D-aspartate+(NMDA)+Stimulation+of+Dopamine+Release+and+Receptor+Subunit+Expression+During+Expression+of+and+Recovery+from+MPTP-Induced+Parkinsonism&rft.creator=Desai%2C+Dr.+Anup&rft.creator=Rothblat%2C+Dr.+David&rft.creator=Schneider%2C+Dr.+Jay&rft.subject=Neurochemistry&rft.description=Normal+and+1-methyl-4-phenyl-1%2C2%2C3%2C6-tetrahydropyridine(MPTP)-treated+cats+were+used+to+examine+changes+in+N-methyl-D-aspartate+(NMDA)+receptor+function.+In+vivo+microdialysis+studies+showed+that+NMDA-stimulated+dopamine+(DA)+release+was+similar+in+the+normal+dorso-lateral+and+ventro-medial+caudate+nucleus.+In+symptomatic+animals%2C+NMDA-stimulated+DA+release+was+significantly+decreased+in+both+striatal+regions.+In+symptomatic+animals%2C+NMDA-stimulated+dopamine+release+was+significantly+decreased+in+both+striatal+regions.+In+recovered+animals%2C+the+dorsal+striatum+and+ventral+striatum+demonstrated+an+upregulation+in+NMDA-stimulated+dopamine+release+compared+to+symptomatic+animals.+Receptor+autoradiography+showed+no+significant+differences+in+NMDA+receptor+binding+between+normal%2C+symptomatic%2C+and+recovered+animals+in+the+dorso-lateral+caudate.+NMDA+receptor+binding+was%2C+however%2C+upregulated+in+the+ventro-medial+caudate+of+recovered+animals.+With+Western+analysis%2C+NR1+and+NR2A+subunit+levels+in+the+dorso-lateral+caudate+were+shown+to+decrease+significantly+in+symptomatic+animals+compared+to+normal+and+then+increase+in+recovered+animals+compared+to+symptomatic+animals.+In+the+ventro-medial+caudate%2C+NR1+and+NR2A+levels+in+the+symptomatic+group+were+significantly+increased+compared+to+normal+and+recovered+groups.+These+data+suggest+that+there+may+be+recovery-induced+changes+in+the+functional+regulation+of+the+NMDA+receptors+in+the+striatum+contributing+to+the+behavioral+recovery+seen+in+this+model.%0A&rft.date=2001&rft.type=Other&rft.type=NonPeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F5006%2F1%2FNMDA_MPTPcat.pdf&rft.identifier=++Desai%2C+Dr.+Anup+and+Rothblat%2C+Dr.+David+and+Schneider%2C+Dr.+Jay++(2001)+Changes+in+Striatal+N-methyl-D-aspartate+(NMDA)+Stimulation+of+Dopamine+Release+and+Receptor+Subunit+Expression+During+Expression+of+and+Recovery+from+MPTP-Induced+Parkinsonism.+++++(Unpublished)++&rft.relation=http%3A%2F%2Fcogprints.org%2F5006%2F