?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=The+Postural+Tachycardia+Syndrome+(POTS)%3A+Pathophysiology%2C+Diagnosis+%26+Management%0A&rft.creator=Raj%2C+Satish+R&rft.subject=Indian+Pacing+and+Electrophysiology+Journal&rft.description=Postural+tachycardia+syndrome+(POTS)%2C+characterized+by+orthostatic+tachycardia+in+the+absence+of+orthostatic+hypotension%2C+has+been+the+focus+of+increasing+clinical+interest+over+the+last+15+years+1.++Patients+with+POTS+complain+of+symptoms+of+tachycardia%2C+exercise+intolerance%2C+lightheadedness%2C+extreme+fatigue%2C+headache+and+mental+clouding.++Patients+with+POTS+demonstrate+a+heart+rate+increase+of+%E2%89%A530+bpm+with+prolonged+standing+(5-30+minutes)%2C+often+have+high+levels+of+upright+plasma+norepinephrine+(reflecting+sympathetic+nervous+system+activation)%2C+and+many+patients+have+a+low+blood+volume.++POTS+can+be+associated+with+a+high+degree+of+functional+disability.++Therapies+aimed+at+correcting+the+hypovolemia+and+the+autonomic+imbalance+may+help+relieve+the+severity+of+the+symptoms.+This+review+outlines+the+present+understanding+of+the+pathophysiology%2C+diagnosis%2C+and+management+of+POTS.%0A&rft.publisher=Indian+Pacing+and+Electrophysiology+Group&rft.contributor=Singh%2C+Balbir&rft.contributor=Lokhandwala%2C+Yash&rft.contributor=Francis%2C+Johnson&rft.contributor=Gupta%2C+Anup&rft.contributor=Ghosh%2C+Joydeep&rft.date=2006-04&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=text%2Fhtml&rft.identifier=http%3A%2F%2Fcogprints.org%2F4802%2F1%2Fraj.htm&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F4802%2F2%2Fraj.pdf&rft.identifier=++Raj%2C+Satish+R++(2006)+The+Postural+Tachycardia+Syndrome+(POTS)%3A+Pathophysiology%2C+Diagnosis+%26+Management.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F4802%2F