?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Digit-Type+Mechanisms+in+Cell+Differentiation+Process%3A+a+Theoretical+Study&rft.creator=Strokovskyy%2C+Yaroslav&rft.subject=Theoretical+Biology&rft.description=According+to+inductive+conception%2C+the+interference+of+neighboring+cells+causes+a+production+of+broken+spatial+symmetry+in+an+initially+homogenous+system+(cell+differentiation+process)+during+embryo+development.+A+concentration+gradient+of+a+specific+substance+(morphogen)%2C+which+serves+as+an+analog-type+control+signal%2C+is+proposed+as+an+agent+to+provide+this+process.+It+is+known+fact%2C+that+genes%E2%80%99+activity+are+of+a+discreet-type+(digit)+and%2C+therefore%2C+cell+differentiation+mechanism+based+on+the+control+digit-type+signals+in+comparison+with+the+analog-type+signals+is+more+or+less+probable.+%0AA+model+presented+here+simulates+the+cell+differentiation+process.+The+model+is+based+on+the+assumption+that+only+the+digit-type+interactions+take+place+between+adjacent+cells+(not+analog-type+interactions+that+are+typical+for+the+concentration+gradient+field).+Within+model+assumptions%2C+the+genes%E2%80%99+interaction+algorithms+and+boundary+condition+are+postulated.%0AUnder+the+model+assumptions%2C+the+cell+differentiation+process+starts+with+the+homogeneous+blastula+formation+and+comprises+three+consecutive+stages.+1)+The+loop-like+inhomogeneous+cell+formation+development+and+corresponding+set+of+the+self-blocking+genes+activation+-+the+set+of+the+asymmetric+pattern+genes+governs+the+process.+2)++The+line-type+inhomogeneous+cell+formations%2C+with+their+origins+at+different+cells+of+the+loop-type+formation%2C+development+and+corresponding+self-blocking+genes+activation+-+the+sets+of+the+symmetric+pattern+genes+govern+the+process.+3)+The+variety+of+the+function+genes+activation+in+the+complex+inhomogeneous+cell+formation+-+the+sets+of+the+self-blocking+genes+govern+the+process.+Under+model+assumptions+the+multi+level+tree-type+inhomogeneous+cell+structures+creation+is+possible.+The+number+of+the+pattern+genes+limits+the+complexity+of+the+inhomogeneous+structure.+According+to+the+model%2C+in+order+to+provide+the+further+blastula+development+process%2C+the+concentration+gradient+fields+may+appear+after+the+initial+stages+of+the+cell+differentiation+process.%0AAs+simulated+by+the+model%2C+results+qualitatively+coincide+with+some+of+the+experimental+facts.%0A&rft.date=2006-04&rft.type=Preprint&rft.type=NonPeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F4743%2F1%2FDigit.PDF&rft.identifier=++Strokovskyy%2C+Yaroslav++(2006)+Digit-Type+Mechanisms+in+Cell+Differentiation+Process%3A+a+Theoretical+Study.++%5BPreprint%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F4743%2F