?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=THE+ROLE+OF+FOLIC+ACID+IN+THE+TREATMENT+OF+MAJOR+DEPRESSIVE+DISORDER&rft.creator=Analan%2C+E&rft.creator=Do%C4%9Fan%2C+O&rft.creator=Aky%C3%BCz%2C+G&rft.subject=JOURNALS&rft.description=Objective%3A+Depressive+symptoms+are+the+most+common+neuropsychiatric+manifestation+of+folic+acid+deficiency.+The+objective+of+this+research+is+to+determine+the+role+of+folic+acid+in+the+treatment+of+major+depressive+disorder+(MDD).+Method%3A+60+outpatients+with+MDD+and+matched+30+healthy+controls+constituted+the+sample.+The+Personal+Information+Form+was+used+to+determine+the+sociodeniographic+features+of+the+patient+and+the+control+groups.+Hamilton+Depression+Rating+Scale+(HDRS)+and+the+criteria+of+MDD+of+DSM-IV+were+used+to+diagnos+the+MDD.+30+of+the+outpatients+randomly+selected+as+first+group+they+were+given+fluoxetine+(20+mgs+per+day)%2C+the+remainders+we+given+fluoxeline+(20+mgs+per+day)+and+folic+acid+(5+mgs+per+day)+as+the+second+group.+HDRS+was+applied+lo+the+patients+in+7%3Csup%3Eth%3C%2Fsup%3E%2C+14%3Csup%3Eth%3C%2Fsup%3E%2C+28%3Csup%3Eth%3C%2Fsup%3E%2C+42%3Csup%3Eth%3C%2Fsup%3E+days+and+to+the+three+groups+at+the+beginning%2C+and+was+measured+serum+folic+acid+levels+0+%3Csup%3Eth%3C%2Fsup%3E%2C+14%3Csup%3Eth%3C%2Fsup%3E%2C.+28+%3Csup%3Eth%3C%2Fsup%3E%2C+42%3Csup%3Eth%3C%2Fsup%3E+days.+After+calculating+HDRS+scores+and+serum+folic+acid+levels%2C+the+data+were+run+on+SPSS.+The+following+statistical+analyses+were+used+in+order+to+evaluate+the+data%3A+variance+analysis%2C+student's+t+test.+Mann-Whitney+U+test+and+Tukey's+test.+Result+At+the+beginning%2C+HDRS+scores+of+first%2C+second+and+control+groups+were+29.10%2C+26.93%2C+7.90+respectively.+The+mean+serum+folate+levels+were+lower+in+the+first+and+the+second+groups+than+It%2C+controls.+The+decrease+of+HDRS+scores+were+found+to+be+faster+in+the+second+group+than+the+first+group.+However%2C+in+42%3Csup%3End%3C%2Fsup%3E+day%2C+the+difference+between+HDRS+scores+of+the+two+groups+was+not+significant+statistically.+Conclusion%3A+As+a+result%2C+one+can+say+that+adding+folate+to+the+treatment+of+MDD+may+reduce+the+occurrence+and+duration+of+MDD+and+increase+the+efficiency+of+antidepressant+treatment.&rft.publisher=Cumhuriyet+University+Faculty+of+Medicine+Department+of+Psychiatry&rft.contributor=Do%C4%9Fan%2C+Orhan&rft.date=2000-01&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F4573%2F1%2F5-12.pdf&rft.identifier=++Analan%2C+E+and+Do%C4%9Fan%2C+O+and+Aky%C3%BCz%2C+G++(2000)+THE+ROLE+OF+FOLIC+ACID+IN+THE+TREATMENT+OF+MAJOR+DEPRESSIVE+DISORDER.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F4573%2F