?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=NEURONIC+SYSTEM+INSIDE+NEURONS%3A+MOLECULAR+BIOLOGY+AND+BIOPHYSICS+OF+NEURONAL+MICROTUBULES&rft.creator=Georgiev%2C+Danko&rft.creator=Papaioanou%2C+Stelios&rft.creator=Glazebrook%2C+James&rft.subject=Biophysics&rft.subject=Neurophysiology&rft.description=Neurons+are+highly+specialized+cells+that+input%2C+process%2C+store+and+output+information.+Interneuronal+communication+is+achieved+in+four+basic+ways%3A+(i)+Ca2%2B+evoked+exocytosis+with+chemical+neurotransmission%2C+(ii)+gap+junction+electrotonic+coupling%2C+(iii)+secretion+of+neurosteroids%2C+nitric+oxide+and+derivatives+of+the+arachidonic+acid+acting+in+paracrine+manner%2C+and+(iv)+cellular+adhesive+protein+interactions+with+scaffold+protein+reorganization.+Central+structure+integrating+these+anisomorphic+signals+is+the+neuronal+cytoskeleton+that+is+considered+to+be+both+sensitive+to+the+local+electromagnetic+%EF%AC%81eld+and+prone+to+intense+biochemical+modi%EF%AC%81cation.+With+the+use+of+biophysical+modeling+we+have+shown+that+the+local+electromagnetic+%EF%AC%81eld+interaction+with+neuronal+microtubules+could+result+in+formation+of+dissipationless+waves+(solitons)+of+tubulin+tail+conformational+states+that+propagate+along+the+microtubule+outer+surface.+Soliton+collisions+may+subserve+the+function+of+elementary+computational+gates+and+the+output+of+the+computation+performed+by+the+microtubules+may+be+achieved+by+the+energase+action+of+the+tubulin+tails+that+control+microtubule-associated+protein+and+motor+protein+attachment%2Fdetachment+on+the+microtubule+outer+surface.&rft.publisher=The+Bulgarian-American+Center%2C+Varna%2C+Bulgaria&rft.contributor=Chaldakov%2C+George&rft.contributor=Marani%2C+Enrico&rft.contributor=Mathison%2C+Ronald&rft.contributor=Yamamoto%2C+Hiroshi&rft.date=2004-08&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F4364%2F1%2FBMR_2004_15_67-75.pdf&rft.identifier=++Georgiev%2C+Danko+and+Papaioanou%2C+Stelios+and+Glazebrook%2C+James++(2004)+NEURONIC+SYSTEM+INSIDE+NEURONS%3A+MOLECULAR+BIOLOGY+AND+BIOPHYSICS+OF+NEURONAL+MICROTUBULES.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F4364%2F