creators_name: Vincent, G. Michael
editors_name: Singh, Balbir
editors_name: Lokhandwala, Yash
editors_name: Francis, Johnson
editors_name: Gupta, Anup
type: journalp
datestamp: 2005-05-02
lastmod: 2011-03-11 08:56:01
metadata_visibility: show
title: The Long QT Syndrome
ispublished: pub
subjects: ipej
full_text_status: public
keywords: cardiac ion channelopathies; Long QT syndrome 
abstract: The Long QT syndrome (LQTS) can be inherited or acquired and is of particular interest and concern at present. Patients with LQTS are predisposed to the ventricular tachyarrhythmia torsade de pointes (TdP) which causes syncope and sudden death. Inherited LQTS is the prototype of the “primary cardiac arrhythmias” or “cardiac ion channelopathies”. The study of inherited LQTS has provided enormous insight into the molecular basis of cardiac electrophysiology and arrhythmogenesis in general. Drug induced LQTS is the most common cause of acquired LQTS, and is a pressing public health issue. Considerable attention has been focussed on this form of LQTS following the withdrawal from the USA market of a number of prescription medications, including terfenedine in 2000 and cisapride in 2001. This review will discuss both forms, but with more emphasis on inherited LQTS.

date: 2002-10
date_type: published
publication: Indian Pacing and Electrophysiology Journal
volume: 2
number: 4
publisher: Indian Pacing and Electrophysiology Group
pagerange: 127-142
refereed: TRUE
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citation:   Vincent, G. Michael  (2002) The Long QT Syndrome.  [Journal (Paginated)]     
document_url: http://cogprints.org/4302/1/vincent.htm