?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Brugada-Like+Electrocardiographic+Pattern&rft.creator=Francis%2C+Johnson&rft.creator=Antzelevitch%2C+Charles&rft.subject=Indian+Pacing+and+Electrophysiology+Journal&rft.description=+The+Brugada+syndrome+is+characterized+by+a+ST-segment+elevation+in+the+right+precordial+leads+associated+with+right+bundle+branch+block+(RBBB)+pattern+and+a+propensity+for+life-threatening+ventricular+arrhythmias+in+the+absence+of+structural+heart+disease.1+Mutations+in+a+cardiac+sodium+channel+gene+have+been+linked+to+this+syndrome2.%0A%0A++++++++++++The+mechanism+underlying+the+RBBB+and+ST-segment+elevation+in+right+precordial+leads+in+patients+with+the+Brugada+syndrome+is+thought+to+be+an+outward+shift+of+the+ionic+currents+during+early+repolarization+causing+a+marked+accentuation+of+the+action+potential+notch+in+right+ventricular+epicardial+but+not+endocardial+cells.+The+outward+shift+of+current+ultimately+leads+to+loss+of+the+action+potential+dome+causing+marked+abbreviation+of+the+action+potential+in+the+right+ventricular+epicardial+cells.3%2C+4%2C&rft.publisher=Indian+Pacing+and+Electrophysiology+Group&rft.contributor=Singh%2C+Balbir&rft.contributor=Lokhandwala%2C+Yash&rft.contributor=Francis%2C+Johnson&rft.contributor=Gupta%2C+Anup&rft.date=2003-07&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=text%2Fhtml&rft.identifier=http%3A%2F%2Fcogprints.org%2F4256%2F1%2Ffrancis3.htm&rft.identifier=++Francis%2C+Johnson+and+Antzelevitch%2C+Charles++(2003)+Brugada-Like+Electrocardiographic+Pattern.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F4256%2F