<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "Current concepts on ventricular fibrillation: A Vicious Circle of Cardiomyocyte Calcium Overload in the Initiation, Maintenance, and Termination of Ventricular Fibrillation\n"^^ . "Based on recent experimental studies, this review article introduces the novel concept that cardiomyocyte Ca2+ and ventricular fibrillation (VF) are mutually related, forming a self-maintaining vicious circle in the initiation, maintenance, and termination of VF. On the one hand, elevated myocyte Ca2+ can cause delayed afterdepolarizations, triggered activity, and consequently life-threatening ventricular tachyarrhythmias in various pathological conditions such as digitalis toxicity, myocardial ischemia, or heart failure. On the other hand, VF itself directly and rapidly causes progressive myocyte Ca2+ overload that maintains VF and renders termination of VF increasingly difficult. Accordingly, energy levels for successful electrical defibrillation (defibrillation thresholds) increase as both VF and Ca2+ overload progress. Furthermore, VF-induced myocyte Ca2+ overload can promote re-induction of VF after defibrillation and/or postfibrillatory myocardial dysfunction (postresuscitation stunning) due to reduced myofilament Ca2+ responsiveness. The probability of these adverse events is best reduced by early detection and rapid termination of VF to prevent or limit Ca2+ overload. Early additional therapy targeting transsarcolemmal Ca2+ entry, particularly during the first 2 min of VF, may partially prevent myocyte Ca2+ overload and thus, increase the likelihood of successful defibrillation as well as prevent postfibrillatory myocardial dysfunction.\n"^^ . "2004-04" . . . "4" . "2" . . "Indian Pacing and Electrophysiology Group"^^ . . . "Indian Pacing and Electrophysiology Journal"^^ . . . . . . . . . . . . . . . . . . . . "Balbir"^^ . "Singh"^^ . "Balbir Singh"^^ . . "Christian"^^ . "E. Zaugg"^^ . "Christian E. Zaugg"^^ . . "Johnson"^^ . "Francis"^^ . "Johnson Francis"^^ . . "Yash"^^ . "Lokhandwala"^^ . "Yash Lokhandwala"^^ . . "Anup"^^ . "Gupta"^^ . "Anup Gupta"^^ . . . . . . "Current concepts on ventricular fibrillation: A Vicious Circle of Cardiomyocyte Calcium Overload in the Initiation, Maintenance, and Termination of Ventricular Fibrillation\n (HTML)"^^ . . . . . . "ipej_but_archives.gif"^^ . . . "ipej_logo_border.gif"^^ . . . "zaugg2.jpg"^^ . . . "zaugg.htm"^^ . . . "zaugg1.jpg"^^ . . . "ipej_but_home.gif"^^ . . . "ipej_but_editors.gif"^^ . . . "ipej.jpg"^^ . . . "ipej_title.gif"^^ . . . "ipej_but_currentissue.gif"^^ . . . "Current concepts on ventricular fibrillation: A Vicious Circle of Cardiomyocyte Calcium Overload in the Initiation, Maintenance, and Termination of Ventricular Fibrillation\n (PDF)"^^ . . . . . . . . . "zaugg.pdf"^^ . . . "Current concepts on ventricular fibrillation: A Vicious Circle of Cardiomyocyte Calcium Overload in the Initiation, Maintenance, and Termination of Ventricular Fibrillation\n (Image (PNG))"^^ . . . . . . "preview.png"^^ . . . "Current concepts on ventricular fibrillation: A Vicious Circle of Cardiomyocyte Calcium Overload in the Initiation, Maintenance, and Termination of Ventricular Fibrillation\n (Indexer Terms)"^^ . . . . . . "indexcodes.txt"^^ . . . "Current concepts on ventricular fibrillation: A Vicious Circle of Cardiomyocyte Calcium Overload in the Initiation, Maintenance, and Termination of Ventricular Fibrillation\n (Indexer Terms)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #4232 \n\nCurrent concepts on ventricular fibrillation: A Vicious Circle of Cardiomyocyte Calcium Overload in the Initiation, Maintenance, and Termination of Ventricular Fibrillation\n\n\n" . "text/html" . . . "Indian Pacing and Electrophysiology Journal" . .