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dc:title "HTML Summary of #3915 \n\nFour basic symmetry types in the universal 7-cluster\nstructure of 143 complete bacterial genomic sequences\n\n";
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bibo:abstract "Coding information is the main source of heterogeneity\n(non-randomness) in the sequences of bacterial genomes. This\ninformation can be naturally modeled by analysing cluster structures in the ``in-phase'' triplet distributions of relatively short genomic fragments (200-400bp). We found a universal 7-cluster structure in all 143 completely sequenced bacterial genomes available in Genbank in August 2004, and explained its properties.\nThe 7-cluster structure is responsible for the main part of sequence heterogeneity in bacterial genomes. In this sense, our 7 clusters is the basic model of bacterial genome sequence. We demonstrated that there are four basic ``pure'' types of this model, observed in nature: ``parallel triangles'', ``perpendicular triangles'',\ndegenerated case and the flower-like type. We show that codon usage of bacterial genomes is a multi-linear function of their genomic G+C-content with high accuracy (more precisely, by two similar functions, one for eubacterial genomes and the other one for archaea).\n\nAll 143 cluster animated 3D-scatters are collected in a database and is made available on our web-site:\n\nhttp://www.ihes.fr/~zinovyev/7clusters \n\nThe finding can be readily introduced into any software for gene prediction, sequence alignment or bacterial genomes classification.\n"^^xsd:string;
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dct:date "2004-10";
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skos:prefLabel "Theoretical Biology" .
foaf:familyName "Zinovyev"^^xsd:string;
foaf:givenName "A.Yu."^^xsd:string;
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foaf:givenName "A.N."^^xsd:string;
foaf:name "A.N. Gorban"^^xsd:string;
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