creators_name: Thomas, Jeffrey creators_name: Nachimuthu, Natarajan creators_name: James, Curtis creators_name: Barbara, Kirsten creators_name: Swede, Helen creators_id: Quirk JT creators_id: Natarajan N creators_id: Mettlin CJ creators_id: Moysich KB creators_id: Swede H editors_name: Kakkilaya, Srinivas editors_id: Dr. B.S. Kakkilaya type: journale datestamp: 2004-10-22 lastmod: 2011-03-11 08:55:43 metadata_visibility: show title: Risk Factors for Invasive Epithelial Ovarian Cancer by Histologic Subtype ispublished: pub subjects: OJHAS full_text_status: public keywords: Epithelial ovarian cancer, Histology, Epidemiology, Case-control study abstract: It is unclear whether the different histologic subtypes of epithelial ovarian carcinoma have different risk factors. We investigated the relationships between selected epidemiologic variables (i.e., parity, family history of ovarian cancer, oral contraceptive use, a history of tubal ligation and noncontraceptive estrogen use) and the major histologic subtypes of epithelial ovarian cancer in a hospital-based case-control study of adult women at Roswell Park Cancer Institute in Buffalo, NY, USA. Multivariate unconditional logistic regression models were used for statistical analysis. We observed a pattern of increased risk associated with family history and a pattern of risk reduction associated with parity, noncontraceptive estrogen use and tubal ligation across all histologic subtype groups. However, we did not observe a consistent pattern of risk associated with oral contraceptive use. These results provide some additional support for the hypothesis that the effects of various ovarian cancer risk factors may differ according to the histologic subtype. date: 2004-10 date_type: published publication: Online Journal of Health and Allied Sciences volume: 3 number: 3 publisher: Dr. B.S. Kakkilaya refereed: TRUE referencetext: 1.Parkin DM, Pisani P. Ferlay J. Global cancer statistics. CA Cancer J Clin 1999; 49:33-64. 2.Scully RE, Young RH, Clement PB. Atlas of Tumor Pathology, Third Series, Fascicle 23: Tumors of the Ovary, Maldeveloped Gonads, Fallopian Tube, and Broad Ligament. Washington, DC: Armed Forces Institute of Pathology, 1998. 3.Auersperg N, Wong AS, Choi KC, et al. Ovarian surface epithelium: biology, endocrinology, and pathology. Endocr Rev 2001;22: 255-88. 4.Weiss NS, Cook LS, Farrow DC, et al. Ovarian cancer. In: Schottenfeld D, Fraumeni JF Jr, editors. Cancer Epidemiology and Prevention, 2nd ed. New York: Oxford; 1996. p. 1040-57. 5.Troisi R, Hartge P. 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