?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=ProtocadherinX%2FY%2C+a+Candidate+Gene-Pair+for+Schizophrenia+and+Schizoaffective+Disorder%3A+A+DHPLC+Investigation+of+Gonomic+Sequence&rft.creator=Giouzeli%2C+Ms+M&rft.creator=Williams%2C+Dr+NA&rft.creator=Lonie%2C+Dr+LJ&rft.creator=DeLisi%2C+Prof+LE&rft.creator=Crow%2C+Prof+TJ&rft.subject=Neurogenetics&rft.description=Protocadherin+X+and+Protocadherin+Y+(PCDHX+and+PCDHY)+are+cell-surface+adhesion+molecules+expressed+predominantly+in+the+brain.+The+PCDHX%2FY+gene-pair+was+generated+by+an+X-Y+translocation+approximately+3+million+years+ago+(MYA)+that+gave+rise+to+the+Homo+sapiens-specific+region+of+Xq21.3+and+Yp11.2+homology.+Genes+within+this+region+are+expected+to+code+for+sexually+dimorphic+human+characteristics%2C+including%2C+for+example%2C+cerebral+asymmetry+a+dimension+of+variation+that+has+been+suggested+is+relevant+to+psychosis.+We+examined+differences+in+patients+with+schizophrenic+or+schizoaffective+psychosis+in+the+genomic+sequence+of+PCDHX+and+PCDHY+in+coding+and+adjacent+intronic+sequences+using+denaturing+high+performance+liquid+chromatography+(DHPLC).+Three+coding+variants+were+detected+in+PCDHX+and+two+in+PCDHY.+However%2C+neither+the+coding+variants+nor+the+intronic+polymorphisms+could+be+related+to+psychosis+within+families.+Low+sequence+variation+suggests+selective+pressure+against+sequence+change+in+modern+humans+in+contrast+to+the+structural+chromosomal+and+sequence+changes+including+fixed+X-Y+differences+that+occurred+in+this+region+earlier+in+hominid+evolution.+Our+findings+exclude+sequence+variation+in+PCDHX%2FY+as+relevant+to+the+aetiology+of+psychosis.+However%2C+we+note+the+unusual+status+of+this+region+with+respect+to+X-inactivation.+Further+investigation+of+the+epigenetic+control+of+PCDHX%2FY+in+relation+to+psychosis+is+warrant&rft.publisher=Wiley-Liss%2C+Inc.&rft.date=2004&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F3879%2F1%2FAJMG2004Giouzeli.pdf&rft.identifier=++Giouzeli%2C+Ms+M+and+Williams%2C+Dr+NA+and+Lonie%2C+Dr+LJ+and+DeLisi%2C+Prof+LE+and+Crow%2C+Prof+TJ++(2004)+ProtocadherinX%2FY%2C+a+Candidate+Gene-Pair+for+Schizophrenia+and+Schizoaffective+Disorder%3A+A+DHPLC+Investigation+of+Gonomic+Sequence.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F3879%2F