?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Quantum+Interactomics+and+Cancer+Molecular+Mechanisms&rft.creator=Baianu%2C+Dr.+I.C.&rft.subject=Dynamical+Systems&rft.subject=Complexity+Theory&rft.subject=Artificial+Intelligence&rft.subject=Theoretical+Biology&rft.description=+++Single+cell+interactomics+in+simpler+organisms%2C+as+well+as+somatic+cell+interactomics+in+multicellular+organisms%2C+involve+biomolecular+interactions+in+complex+signalling+pathways+that+were+recently+represented+in+modular+terms+by+quantum+automata+with+%E2%80%98reversible+behavior%E2%80%99+representing+normal+cell+cycling+and+division.+Other+implications+of+such+quantum+automata%2C+modular+modeling+of+signaling+pathways+and+cell+differentiation+during+development+are+in+the+fields+of+neural+plasticity+and+brain+development+leading+to+quantum-weave+dynamic+patterns+and+specific+molecular++processes+underlying+extensive+memory%2C+learning%2C+anticipation+mechanisms+and+the+emergence+of+human+consciousness+during+the+early+brain+development+in+children.+Cell+interactomics+is+here+represented+for+the+first+time+as+a+mixture+of+%E2%80%98classical%E2%80%99+states+that+determine+molecular+dynamics+subject+to+Boltzmann+statistics+and+%E2%80%98steady-state%E2%80%99%2C+metabolic+(multi-stable)+manifolds%2C+together+with+%E2%80%98configuration%E2%80%99+spaces+of+metastable+quantum+states+emerging+from+complex+quantum+dynamics+of+interacting+networks+of+biomolecules%2C+such+as+proteins+and+nucleic+acids+that+are+now+collectively+defined+as+quantum+interactomics.+On+the+other+hand%2C+the+time+dependent+evolution+over+several+generations+of+cancer+cells+--that+are+generally+known+to+undergo+frequent+and+extensive+genetic+mutations+and%2C+indeed%2C+suffer+genomic+transformations+at+the+chromosome+level+(such+as+extensive+chromosomal+aberrations+found+in+many+colon+cancers)--+cannot+be+correctly+represented+in+the+%E2%80%98standard%E2%80%99+terms+of+quantum+automaton+modules%2C+as+the+normal+somatic+cells+can.+This+significant+difference+at+the+cancer+cell+genomic+level+is+therefore+reflected+in+major+changes+in+cancer+cell+interactomics+often+from+one+cancer+cell+%E2%80%98cycle%E2%80%99+to+the+next%2C+and+thus+it+requires+substantial+changes+in+the+modeling+strategies%2C+mathematical+tools+and+experimental+designs+aimed+at+understanding+cancer+mechanisms.+Novel+solutions+to+this+important+problem+in+carcinogenesis+are+proposed+and+experimental+validation+procedures+are+suggested.+From+a+medical+research+and+clinical+standpoint%2C+this+approach+has+important+consequences+for+addressing+and+preventing+the+development+of+cancer+resistance+to+medical+therapy+in+ongoing+clinical+trials+involving+stage+III+cancer+patients%2C+as+well+as+improving+the+designs+of+future+clinical+trials+for+cancer+treatments.%0A*Communicated+to%3A+The+Institute+of+Genomic+Biology+(currently+under+construction+at+UIUC%2C+at+905+S.+Goodwin+Avenue%2C+Urbana%2CIL.61801%2CUSA).%0A+%0AKEYWORDS%3A+%09%09Cancer+cell+interactomics%3B+Somatic+cell+genomics+and+%0AProteomics%3B+current+limitations+of+modular+models+of+carcinogenesis%3B%0AComplex+quantum+dynamics%3B+Quantum+Automata+models+and+Quantum+Interactomics%3B+quantum-weave+dynamic+patterns+underlying+human+consciousness%3B+specific+molecular++processes+underlying+extensive+memory%2C+learning%2C+anticipation+mechanisms+and+human+consciousness%3B++emergence+of+human+consciousness+during+the+early+brain+development+in+children%3B+Cancer+cell+%E2%80%98cycling%E2%80%99%3B+interacting+networks+of+proteins+and+nucleic+acids%3B+genetic+mutations+and+chromosomal+aberrations+in+cancers%2C+such+as+colon+cancer%3B+development+of+cancer+resistance+to+therapy%3B+ongoing+clinical+trials+involving+stage+III+cancer+patients%E2%80%99+possible+improvements+of++the+designs+for+future+clinical+trials+and+cancer+treatments.+%0A%0A&rft.publisher=Elsevier+Publs.+Co.&rft.contributor=Witten%2C+Professor+Matthew&rft.date=1987-09&rft.type=Departmental+Technical+Report&rft.type=PeerReviewed&rft.format=text%2Fhtml&rft.identifier=http%3A%2F%2Fcogprints.org%2F3810%2F1%2FQUANTUM__INTERACTOMICS__AND__CANCER.htm&rft.identifier=++Baianu%2C+Dr.+I.C.++(1987)+Quantum+Interactomics+and+Cancer+Molecular+Mechanisms.++%5BDepartmental+Technical+Report%5D++++(In+Press)++&rft.relation=http%3A%2F%2Fcogprints.org%2F3810%2F