creators_name: Crusio, Wim E. type: journalp datestamp: 1998-05-07 lastmod: 2011-03-11 08:53:37 metadata_visibility: show title: Bi- and Multivariate Analyses of Diallel Crosses: A Tool for the Genetic Dissection of Neurobehavioral Phenotypes ispublished: pub subjects: behav-neuro-sci full_text_status: public keywords: diallel cross, genetic correlations, multivariate analysis, brain-behavior relationships, neurobehavioral genetics, exploratory activity, mouse abstract: The genetic-correlational approach provides a very powerful tool for the analysis of causal relationships between phenotypes. It appears to be particularly appropriate for investigating the functional organization of behavior and/or of causal relationships between brain and behavior. A method for the bivariate analysis of diallel crosses that permits the estimation of correlations due to environmental effects, additive-genetic effects, and/or dominance deviations is described, together with a worked-out example stemming from a five times replicated 4 x 4 diallel cross between inbred mouse strains. The phenotypes chosen to illustrate the analysis were locomotor activity and rearing frequency in an open field. Large, positive additive-genetic and dominance correlations between these two phenotypes were obtained. This finding was replicated in another, independently-executed, diallel cross. date: 1993 date_type: published publication: Behavior Genetics volume: 23 pagerange: 59-67 refereed: TRUE citation: Crusio, Wim E. (1993) Bi- and Multivariate Analyses of Diallel Crosses: A Tool for the Genetic Dissection of Neurobehavioral Phenotypes. [Journal (Paginated)] document_url: http://cogprints.org/33/1/diallel2.htm