?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=A+Multivariate+Quantitative-Genetic+Analysis+of+Behavioral+Development+in+Mice&rft.creator=Crusio%2C+Wim+E.&rft.creator=Schmitt%2C+Andrea&rft.subject=Behavioral+Neuroscience&rft.description=The+present+experiment+attempted+a+behavior-genetic+dissection+of+early+behavioral+development+in+laboratory+mice.+To+this+end%2C+we+used+a+full%2C+replicated+diallel+cross+to+uncover+the+genetical+architecture+as+well+as+the+multivariate+genetic+structure+underlying+early+behavioral+ontogeny.+A+number+of+standard+sensory-motor+tests+were+administered+on+postnatal+days+3%2C+5%2C+8%2C+10%2C+13%2C+17%2C+and+22+to+a+total+of+622+pups+from+120+litters+(4-6+pups+per+litter)+from+a+4+times+replicated+complete+diallel+cross+between+five+inbred+mouse+strains.+The+first+day+on+which+an+animal+showed+adult+performance+was+taken+as+its+score+on+that+test.+MANOVA+did+not+show+any+effects+of+the+pup's+sex+on+the+speed+of+development.+Hayman's+analysis+of+variance+for+diallel+tables+indicated+no+or+only+weak+additive-genetic+effects.+Dominance+was+absent+in+almost+all+cases%2C+except+for+the+auricular+startle+response%2C+where+weak+directional+dominance+for+fast+development+was+found.+These+results+are+in+accordance+with+an+evolutionary+past+of+directional+selection+for+well-canalized+development.+Factor+analyses+of+the+phenotypic+and+additive-genetic+correlation+matrices+indicate+that+at+least+two+factors+are+necessary+to+describe+the+behavioral+variation.&rft.date=1998&rft.type=Preprint&rft.type=PeerReviewed&rft.format=text%2Fhtml&rft.identifier=http%3A%2F%2Fcogprints.org%2F32%2F1%2Fdevelopm.htm&rft.identifier=++Crusio%2C+Wim+E.+and+Schmitt%2C+Andrea++(1998)+A+Multivariate+Quantitative-Genetic+Analysis+of+Behavioral+Development+in+Mice.++%5BPreprint%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F32%2F