--- abstract: | So far, cognitive derangements in MND/ALS have not been widely studied. Nevertheless, it seems that in subgroups of patients cognitive functions are impaired in different degree, so that often at least two sub-types of the syndrome are reported: Motor Neuron Disease/Amyotrophic Lateral Sclerosis/Dementia Syndrome (MND/ALS/DS) and Motor Neuron Disease/Amyotrophic Lateral Sclerosis/ Aphasia Syndrome (MND/ALS/AS. A third subtype showing both symptoms of cognitive impairment may be identified in subgroups of patients and denominated Motor Neuron Disease/Amyotrophic Lateral Sclerosis/Dementia-Aphasia Syndrome (MND/ALS/DAS). Frontostriatal system is reported as a network heavily damaged in MND/ALS/DS, MND/ALS/AS, MND/ALS/DAS. The system is plausibly responsible of motor skills and verbs production, hence to become aware of a possible frontostriatal deficit in subgroup of MND/ALS patients might consent us to link at the brain level (motor) action and verbs and possibly ideomotor praxia and verbs. We have used Goal-Oriented Perception Task (GOPT) and Action Fluency Task (AFT) in order to detect with some accuracy impairments related to gestaltic analysis directed toward a goal, and verb retrieval deficits possibly underlying executive system dysfunction that destabilizes the ability to mentally coordinate the information associated with a verb. These tests should consent to detect possible frontostriatal derangements. We have tested 10 MND/ALS patients and 10 healthy subjects matched fore age, sex and laterality. AFT showed that 3 out of 6 patients are heavily impaired in this test (6.3 (mean) verbs generated vs 13.3 of the control group). GOPT detected a remarkable impairment in all patients: p=0.0021 (grammatical side), p=0.0002 (perceptual side). Reported frontostriatal deficit in MND/ALS seems confirmed by this study, and probably it is more easily detected by GOPT than by AFT. altloc: [] chapter: ~ commentary: ~ commref: ~ confdates: 26-31 January 2003 conference: Twenty-First European Workshop on Cognitive Neuropsychology confloc: 'Bressanone, Italy' contact_email: ~ creators_id: [] creators_name: - family: Buoiano given: G honourific: Dr. lineage: '' - family: Bongioanni given: P honourific: Dr. lineage: '' - family: Magoni given: M honourific: Dr. lineage: '' - family: Carboncini given: MC honourific: Dr. lineage: '' - family: Rossi given: B honourific: Dr. lineage: '' date: 2003 date_type: published datestamp: 2003-09-04 department: ~ dir: disk0/00/00/31/29 edit_lock_since: ~ edit_lock_until: ~ edit_lock_user: ~ editors_id: [] editors_name: [] eprint_status: archive eprintid: 3129 fileinfo: /style/images/fileicons/application_pdf.png;/3129/1/Frontostriatal_Deficit_in_MND%2DALS.pdf full_text_status: public importid: ~ institution: ~ isbn: ~ ispublished: unpub issn: ~ item_issues_comment: [] item_issues_count: 0 item_issues_description: [] item_issues_id: [] item_issues_reported_by: [] item_issues_resolved_by: [] item_issues_status: [] item_issues_timestamp: [] item_issues_type: [] keywords: 'amiotrophic lateral sclerosis, motor neuron disease, frontostriatal deficit' lastmod: 2011-03-11 08:55:20 latitude: ~ longitude: ~ metadata_visibility: show note: ~ number: ~ pagerange: ~ pubdom: FALSE publication: ~ publisher: ~ refereed: TRUE referencetext: | 1. 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