?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Frontostriatal+deficit+in+Motor+Neuron+Disease%2FAmyotrophic+Lateral+Sclerosis+(MND%2FALS)&rft.creator=Buoiano%2C+Dr.+G&rft.creator=Bongioanni%2C+Dr.+P&rft.creator=Magoni%2C+Dr.+M&rft.creator=Carboncini%2C+Dr.+MC&rft.creator=Rossi%2C+Dr.+B&rft.subject=Neuropsychology&rft.description=So+far%2C+cognitive+derangements+in++MND%2FALS+have+not+been+widely+studied.+Nevertheless%2C+it+seems+that+in+subgroups+of+patients+cognitive+functions+are+impaired+in+different+degree%2C+so+that+often+at+least+two+sub-types+of+the+syndrome+are+reported%3A+Motor+Neuron+Disease%2FAmyotrophic+Lateral+Sclerosis%2FDementia+Syndrome+(MND%2FALS%2FDS)+and+Motor+Neuron+Disease%2FAmyotrophic+Lateral+Sclerosis%2F+Aphasia+Syndrome+(MND%2FALS%2FAS.+A+third+subtype+showing+both+symptoms+of+cognitive+impairment+may+be+identified+in+subgroups+of+patients+and+denominated+Motor+Neuron+Disease%2FAmyotrophic+Lateral+Sclerosis%2FDementia-Aphasia+Syndrome+(MND%2FALS%2FDAS).%0AFrontostriatal+system+is+reported+as+a+network+heavily+damaged+in+MND%2FALS%2FDS%2C+MND%2FALS%2FAS%2C+MND%2FALS%2FDAS.+The+system+is+plausibly+responsible+of+motor+skills+and+verbs+production%2C+hence+to+become+aware+of+a+possible+frontostriatal+deficit+in+subgroup+of+MND%2FALS+patients+might+consent+us+to+link+at+the+brain+level+(motor)+action+and+verbs+and+possibly+ideomotor+praxia+and+verbs.+%0AWe+have+used+Goal-Oriented+Perception+Task+(GOPT)+and+Action+Fluency+Task+(AFT)+in+order+to+detect+with+some+accuracy+impairments+related+to+gestaltic+analysis+directed+toward+a+goal%2C+and+verb+retrieval+deficits+possibly+underlying+executive+system+dysfunction+that+destabilizes+the+ability+to+mentally+coordinate+the+information+associated+with+a+verb.+These+tests+should+consent+to+detect+possible+frontostriatal+derangements.%0AWe+have+tested+10+MND%2FALS+patients+and+10+healthy+subjects+matched+fore+age%2C+sex+and+laterality.++++%0AAFT+showed+that+3+out+of+6+patients+are+heavily+impaired+in+this+test+(6.3+(mean)+verbs+generated+vs+13.3+of+the+control+group).+GOPT+detected+a+remarkable+impairment+in+all+patients%3A+p%3D0.0021+(grammatical+side)%2C+p%3D0.0002+(perceptual+side).%0AReported+frontostriatal+deficit+in+MND%2FALS+seems+confirmed+by+this+study%2C+and+probably+it+is+more+easily+detected+by+GOPT+than+by+AFT.%0A&rft.date=2003&rft.type=Conference+Poster&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F3129%2F1%2FFrontostriatal_Deficit_in_MND-ALS.pdf&rft.identifier=++Buoiano%2C+Dr.+G+and+Bongioanni%2C+Dr.+P+and+Magoni%2C+Dr.+M+and+Carboncini%2C+Dr.+MC+and+Rossi%2C+Dr.+B++(2003)+Frontostriatal+deficit+in+Motor+Neuron+Disease%2FAmyotrophic+Lateral+Sclerosis+(MND%2FALS).++%5BConference+Poster%5D++++(Unpublished)++&rft.relation=http%3A%2F%2Fcogprints.org%2F3129%2F