?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Regulation+of+Neuromodulator+Receptor+Efficacy-+Implications+for+Whole-Neuron+and+Synaptic+Plasticity&rft.creator=Scheler%2C+Dr.+Gabriele&rft.subject=Computational+Neuroscience&rft.subject=Theoretical+Biology&rft.subject=Neuropharmacology&rft.description=Membrane+receptors+for+neuromodulators+(NM)+are+highly+regulated+in+their+distribution+and+efficacy+-+a+phenomenon+which+influences+the+individual+cell's+response+to+central+signals+of+NM+release.%0AEven+though+NM+receptor+regulation+is+implicated+in+the+pharmacological+action+of+many+drugs%2C+and+is+also+known+to+be+influenced+by+various+environmental+factors%2C+its+functional+consequences+and+modes+of+action+are+not+well+understood.%0AIn+this+paper+we+summarize+relevant+experimental+evidence+on+NM+receptor+regulation+(specifically+dopamine+D1+and+D2+receptors)+in+order+to+explore+its+significance+for+neural+and+synaptic+plasticity.%0AWe+identify+the+relevant+components+of+NM+receptor+regulation+(receptor+phosphorylation%2C+receptor%0Atrafficking+and+sensitization+of+second-messenger+pathways)%0Agained+from+studies+on+cultured+cells.%0AKey+principles+in+the+regulation+and+control+of+short-term+plasticity+(sensitization)+are+identified%2C+and+a+model+is+presented+which+employs+direct+and+indirect+feedback+regulation+of+receptor+efficacy.+We+also+discuss+long-term+plasticity+which+involves+shifts+in+receptor+sensitivity+and+loss+of+responsivity+to+NM+signals.%0AFinally%2C+we+discuss+the+implications+of+NM+receptor+regulation+for+models%0Aof+brain+plasticity+and+memorization.We+emphasize+that+a+realistic+model+of+brain+plasticity+will+have+to+go%0Abeyond+Hebbian+models+of+long-term+potentiation+and+depression+to+include%0Aplasticity+in+the+distribution+and+efficacy+of+NM+receptors.%0A%0A%0A&rft.date=2003-02&rft.type=Preprint&rft.type=NonPeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F2836%2F1%2Fnetwork03.pdf&rft.identifier=++Scheler%2C+Dr.+Gabriele++(2003)+Regulation+of+Neuromodulator+Receptor+Efficacy-+Implications+for+Whole-Neuron+and+Synaptic+Plasticity.++%5BPreprint%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F2836%2F