?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Chronic+infection%3A+punctuated+interpenetration+and+pathogen+virulence&rft.creator=Wallace%2C+Rodrick&rft.creator=Wallace%2C+Robert+G.&rft.subject=Theoretical+Biology&rft.description=We+apply+an+information+dynamics+formalism+to+the+Levens+and+Lewontin+vision+of+biological+interpenetration+between+a+'cognitive+condensation'+including+immune+function+embedded+in+social+and+cultural+structure+on+the+one+hand%2C+and+an+established%2C+highly+adaptive%2C+parasite+population+on+the+other.+We+iterate+the+argument%2C+beginning+with+direct+interaction+between+cognitive+condensation+and+pathogen%2C+then+extend+the+analysis+to+second+order+'mutator'+mechanisms+inherent+both+to+immune+function+and+to+certain+forms+of+rapid+pathogen+antigenic+variability.++%0A%0AThe+methodology%2C+based+on+the+Large+Deviations+Program+of+applied+probability%2C+produces+synergistic+cognitive%2Fadaptive+'learning+plateaus'+that+represent+stages+of+chronic+infection%2C+and%2C+for+human+populations%2C+is+able+to+encompass+the+fundamental+biological+reality+of+culture+omitted+by+other+approaches.%0A%0AWe+conclude+that%2C+for+'evolution+machine'+pathogens+like+HIV+and+malaria%2C+simplistic+magic+bullet+'medical'+drug%2C+vaccine%2C+or+behavior+modification+interventions+which+do+not+address+the+critical+context+of+overall+living+and+working+conditions+may+constitute+selection+pressures+triggering+adaptations+in+life+history+strategy+resulting+in+marked+increase+of+pathogen+virulence&rft.date=2003-02&rft.type=Preprint&rft.type=NonPeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F2763%2F1%2Fchronic9.pdf&rft.identifier=++Wallace%2C+Rodrick+and+Wallace%2C+Robert+G.++(2003)+Chronic+infection%3A+punctuated+interpenetration+and+pathogen+virulence.++%5BPreprint%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F2763%2F