?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Novelty-elicited+mismatch+negativity+in+patients+with+schizophrenia+on+admission+and+discharge&rft.creator=Grzella%2C+&rft.creator=M%C3%BCller%2C+&rft.creator=Oades%2C+&rft.creator=Bender%2C+&rft.creator=Schall%2C+&rft.creator=Zerbin%2C+&rft.creator=Wolstein%2C+&rft.creator=Sartory%2C+&rft.subject=Neurophysiology&rft.subject=Neuropsychiatry&rft.subject=Perceptual+Cognitive+Psychology&rft.subject=Psychophysiology&rft.description=Introduction%3A+%0AMMN%2C+an+electrophysiological+measure+of+auditory+working+memory%2C+is+usually+recorded+as+the+difference+in+the+event-related+potential+(ERP)+elicited+by+a+rare+deviant+and+a+common+standard+sound.+The+amplitude+is+usually+reduced+in+patients+with+schizophrenia+(refs+below).+Here+we+looked+at+the+response+in+the+extreme+and+most+simple+case+of+the+deviant+being+always+a+novel%2C+different+tone+on+every+presentation.+We+compared+the+novelty-MMN+with+clinical+symptoms+expressed+-+both+measures+being+made+soon+after+admission+and+again+2-3+months+later+just+before+discharge.+%0A%0AMethods%3A+%0AWe+compared+20+patients+(mean+age+26y)+with+a+first%2C+second+or+third+episode+of+schizophrenia+on+admission+with+21+healthy+controls+(mean+age+26y)+and+were+able+to+repeat+the+measures+with+12+patients+at+discharge+and+with+15+controls.+An+early+MMN+component+(80-140+ms)%2C+a+later+component+(140-300+ms)+and+the+P3a+were+recorded+and+topography+examined+after+min-max+norming+from+19+sites.+Symptoms+were+assessed+with+the+positive+and+negative+syndrome+scale+(PANSS).%0A%0AResults%3A+%0Aa)+Novelty-elicited+MMN+was+not+significantly+reduced+on+admission.%0Ab)+The+early+component+remained+unaltered%2C+but+the+amplitude+of+the+later+component+decreased+significantly+during+inpatient+treatment.+While+the+decrease+appeared+significant+over+the+left+hemisphere+in+the+raw+data%2C+the+lateral+difference+was+lost+after+normalizing+the+data.+%0Ac)+Improved+positive+symptom+ratings+were+associated+with+increases+of+the+early+component+latency%2C+but+decreases+of+the+late+component+latency.%0Ad)+P3a+at+Fz+showed+an+increased+latency+between+sessions+in+the+patients+but+there+were+no+group+differences+in+amplitude.+%0A%0AConclusions%3A+%0AOur+results+are+partially+consistent+with+two+other+studies+using+a+conventional+MMN+that+showed+a+lack+of+MMN+normalization+where+symptoms+improved+(Schall+et+al.%2C+1998%3B+Umbricht+et+al.%2C+1998)+-+in+the+present+study+MMN+deteriorated.+While+trait+features+have+been+attributed+to+conventional+MMN+reductions+in+schizophrenia%2C+our+results+suggest+that+if+novelty+responses+are+impaired+in+patients+with+schizophrenia+then+the+differences+may+be+sensitive+to+state.%0A%0A&rft.publisher=Canadian+Medical+Association&rft.date=2001&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F2050%2F2%2FSchiz-J-Psychiat-Nsci-Grzella-2001-art.pdf&rft.identifier=++Grzella%2C++and+M%C3%BCller%2C++and+Oades%2C++and+Bender%2C++and+Schall%2C++and+Zerbin%2C++and+Wolstein%2C++and+Sartory%2C+++(2001)+Novelty-elicited+mismatch+negativity+in+patients+with+schizophrenia+on+admission+and+discharge.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F2050%2F