?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Normal+Repetitive+Firing+and+Its+Pathophysiology&rft.creator=Calvin%2C+William+H&rft.subject=Neurophysiology&rft.description=A+neuron+communicates+over+long+distances+(more+than+a+few+millimeters)+by+generating+a+train+of+impulses+which+propagates+down+the+axon+to+release+a+series+of+prepackaged+quanta+of+neurotransmitter+molecules.+The+rate%2C+or+perhaps+the+patterning%2C+of+the+impulse+train+carries+the+information.+One+of+the+hallmarks+of+an+interictal+epileptogenic+focus+is+that+many+of+its+neurons+are+observed+to+cluster+their+impulses+into+bursts%2C+with+the+intervals+between+impulses+being+unusually+short+(several+milliseconds).+Is+the+bursting+neuron+some+sort+of+pacemaker%2C+driving+other+normal+neurons+into+synchronous+activity+and+thus+spreading+the+trouble%3F+Or+is+the+bursting+one+observes+just+one+of+those+recruited+neurons%2C+having+nothing+more+wrong+with+it+than+an+oversized+synaptic+input%3F+Or+perhaps+there+are+no+pacemaker+neurons%3B+the+trouble+could+be+subtly+distributed+over+many+neurons%2C+changing+the+balance+of+excitation+and+inhibition+so+that+the+whole+circuit+tends+to+go+into+a+bursting-type+oscillation.&rft.publisher=Raven+Press.+New+York&rft.contributor=Lockard%2C+J&rft.contributor=Ward%2C+A+A&rft.date=1980&rft.type=Book+Chapter&rft.type=NonPeerReviewed&rft.format=text%2Fhtml&rft.identifier=http%3A%2F%2Fcogprints.org%2F20%2F1%2F1980pathophysiol.htm&rft.identifier=++Calvin%2C+William+H++(1980)+Normal+Repetitive+Firing+and+Its+Pathophysiology.++%5BBook+Chapter%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F20%2F