?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Impairments+of+search+behaviour+in+rats+after+haloperidol+treatment%2C+hippocampal+or+neocortical+damage+suggest+a+mesocorticolimbic+role+in+cognition&rft.creator=Oades%2C+&rft.subject=Behavioral+Neuroscience&rft.subject=Neuropharmacology&rft.subject=Psychobiology&rft.description=Introduction%3A+%0AIn+view+of+reports+that+fimbria-fornix+or+hippocampal+lesions+impair+working+rather+than+reference+memory+in+a+radial+maze+(Olton+et+al.%2C+1979)+the+performance+of+rodents+with+hippocampal+damage+was+examined+on+a+hole-board+search+task.%0A%0AMethods%3A%0AFood-deprived+animals+searched+for+food+pellets+placed+consistently+in+4+holes+of+a+16-hole-board+(figure+1).+They+were+presented+with+11+sessions+of+10+trials%2Fsession.+There+were+three+groups+of+animals%2C+-+one+with+aspiration+lesions+of+the+hippocampus+and+overlying+neocortex%2C+one+with+damage+only+to+the+overlying+neocortex+and+sham-controls+that+went+through+the+procedure+but+the+brain+was+left+intact+(Oades+and+Isaacson%2C+1978).+Half+of+each+group+received+haloperidol+(0.275+mg%2Fkg)+or+saline+injections+15+minutes+before+each+of+the+sessions+4-10.%0AWorking+memory+error+%3D+a+visit+to+a+correct+hole+that+has+just+been+visited%2C+and+thus+no+longer+contains+a+food+pellet.%0AReference+memory+error+%3D+visit+to+a+hole+that+is+never+baited.%0A%0AResults%3A+%0A1%2F+Hippocampal+damage+resulted+in+poorer+performance+on+both+working+and+reference+memory+measures%3A+this+was+unaffected+by+haloperidol+treatment.%0A2%2F+Neuroleptic+treatment+also+impaired+the+performance+of+the+sham-controls+on+both+measures.%0A3%2F+Animals+with+neocortical+damage+were+impaired+on+reference+mmeory+measures+alon%2C+after+haloperidol+treatment.%0A%0AConclusions%3A%0A.The+lack+of+a+neuroleptic+effect+on+performance+after+hippocampal+damage+suggests+that+this+lesion+does+not+impair+performance+on+these+two+measures+of+memory+performance+through+a+dopaminergic+mechanism.+%0AHaloperidol+impaired+working+memory+measures+in+sham-controls%2C+but+only+reference+memory+measures+in+the+neocortical+group..+The+results+imply+that+there+are+(at+least)+three+separate+mechanisms+(i.e.+meso-cortico-limbic+interactions)+at+work+here+involved+in+shorter-+and+longer-term+consolidation+of+the+consequences+of+selective+attention+mechanism+required+to+efficiently+learn+a+search+task.&rft.publisher=North-Holland&rft.date=1981&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F1503%2F2%2Frat-biol-psychol-81.pdf&rft.identifier=++Oades%2C+++(1981)+Impairments+of+search+behaviour+in+rats+after+haloperidol+treatment%2C+hippocampal+or+neocortical+damage+suggest+a+mesocorticolimbic+role+in+cognition.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F1503%2F