?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=The+role+of+noradrenaline+in+tuning+and+dopamine+in+switching+between+signals+in+the+CNS&rft.creator=Oades%2C+R.D.&rft.subject=Behavioral+Neuroscience&rft.subject=Behavioral+Biology&rft.subject=Neurochemistry&rft.subject=Neurophysiology&rft.subject=Physiological+Psychology&rft.subject=Psychobiology&rft.description=Introduction-+Thesis%3A+%0ANeuronal+catecholaminergic+activity+modulates+central+nervous+(CNS)+function.+-+Specifically+-%0ANoradrenaline+(NA)+can+exert+a+tuning+or+biassing+function%2C+whereby+the+signal-to-noise+ratio+is+altered.%0ADopamine+(DA)+activity+may+promote+switching+between+inputs+and+outputs+of+information+to+specific+brain+regions.%0A%0ABackground%3A%0AIt+has+been+ten+years+since+evidence+for+a+tuning+function+was+advanced+for+NA+(Segal+%26+Bloom%2C+1976+a%2C+b)%2C+and+in+the+last+five+years+the+switching+hypothesis+for+DA+has+been+tentatively+put+forward+(Cools%2C+1980).%0A%0AReview%3A+%0ARecent+studies+are+reviewed+to+show+that+while+catecholamine+activity+contributes+to+neural+interactions+in+separate+brain+regions%2C+that+give+rise+to+the+organization+of+different+functions%2C+their+working+principles+may+be+common+between+species+and+independent+of+the+nucleus+of+origin.+Behavioral+examples+are+discussed+and+an+attempt+is+made+to+integrate+this+with+evidence+from+intracellular+recording+studies.+It+is+suggested+that+the+tuning+principle+in+NA+systems+is+particularly+important+for+the+formation+of+associations+and+neural+plasticity+(interference+control)%2C+and+that+the+switching+principle+of+DA+systems+modulates+the+timing%2C+time-sharing+and+initiation+of+responses+(program-control).%0A%0A&rft.publisher=Ankho+Int+Inc&rft.date=1985&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F1436%2F2%2Fda-switch-rev-85.pdf&rft.identifier=++Oades%2C+R.D.++(1985)+The+role+of+noradrenaline+in+tuning+and+dopamine+in+switching+between+signals+in+the+CNS.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F1436%2F