?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Dopamine-sensitive+alternation+and+collateral+behaviour+in+a+Y-maze%3A+effects+of+d-amphetamine+and+haloperidol&rft.creator=Oades%2C+R.D.&rft.creator=Taghzouti%2C+K.&rft.creator=Simon%2C+H.&rft.creator=Le+Moal%2C+M.&rft.subject=Behavioral+Neuroscience&rft.subject=Behavioral+Biology&rft.subject=Neuropharmacology&rft.subject=Physiological+Psychology&rft.subject=Psychobiology&rft.description=Introduction%3A+%0AThe+frequency+of+spontaneous+alternation+in+a+Y-maze+(visiting+each+arm+in+turn+at+p%3E50%25)+depends+on+the+influence+of+the+attention+given+to+intra-+and+extra-maze+cues.+%0AWe+examined+the+observing+responses+shown+by+rats+(collateral+rearing+and+head-turning+behaviour)%2C+the+habituation+to+the+novelty+and+alternation+responses+over+15+minutes%2Fday%2C+four+days+in+a+row+-+in+a+Y-maze+under+enhanced+and+reduced+dopamine+(DA)+activity+(amphetamine-+and+haloperidol+treatment).%0AMethods%3A%0APrior+to+placement+in+a+Y-maze+for+15+minutes+observation+on+4+successive+days+animals+were+treated+with+either+amphetamine+(0.5+or+2.5+mg%2Fkg)+or+pre-treated+with+a+low+dose+of+haloperidol+(0.08+mg%2Fkg%2C+ip).%0AResults%3A+%0A1%2F+Amphetamine+treated+animals+chose+the+arms+at+random+on+day+1%2C+but+after+the+higher+dose+on+day+2-4+they+perseverated+their+choice.+The+controls+maintained+their+alternation+over+this+period.%0A2%2F+The+amphetamine-induced+effects+on+alternation+were+prevented+by+prior+treatment+with+the+neuroleptic+haloperidol.%0A3%2F+Amphetamine+treatment+increased+the+frequency+of+rearing+in+the+middle+at+the+choice+point+of+the+Y-maze.+Haloperidol+pre-treatment+blocked+this+increase+at+the+midpoint+on+day+1%2C+and+blocked+the+rearing+behavior+at+the+end+of+an+arm+on+day+2.%0A4%2F+Amphetamine+also+increased+the+frequency+of+head+turning+and+%22looking%22%2C+-+an+effect+that+was+also+prevented+by+haloperidol.+(day+2+onwards).%0A5%2F+Haloperidol+increased+the+duration+of%22+looking%22+and+of+rearing+at+the+end+of+an+arm+later+in+testing..+%0AConclusions%3A%0ATwo+effects+are+postulated+to+have+occurred.%0Aa)+a+conflict+on+day+1+between+the+novelty-controlled+sensory+or+attentional+effects%2C+that+leads+to+an+alternation+of+arm-choice%2C+and+amphetamine-induced+DA+activity+that+facilitates+an+alternation+of+behavioural+responses%3A+--+the+result+was+random+choice+and+increased+rearing+at+the+choice+point.%0Ab)+On+days+2-4+the+drug-induced+effects+on+switching+motor+responses+came+to+control+behaviour+%0A&rft.publisher=Springer-Verlag&rft.date=1985&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F1435%2F2%2Frat-amph-85.pdf&rft.identifier=++Oades%2C+R.D.+and+Taghzouti%2C+K.+and+Simon%2C+H.+and+Le+Moal%2C+M.++(1985)+Dopamine-sensitive+alternation+and+collateral+behaviour+in+a+Y-maze%3A+effects+of+d-amphetamine+and+haloperidol.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F1435%2F