title: Locomotor activity in relation to dopamine and noradrenaline in the nucleus accumbens, septal and frontalk areas: a 6-hydroxydopamine study
creator: Oades, R.D.
creator: Taghzouti, K.
creator: Rivet, J-M.
creator: Simon, H.
creator: Le Moal, M.
subject: Behavioral Neuroscience
subject: Behavioral Biology
subject: Neuropharmacology
subject: Psychobiology
description: The Study and the Method:  The locomotor activity of adult male Sprague-Dawley was automatically recorded in a circular corridor - circadian changes are described as well as the response to the novel situation and its habituation over three hours. Four groups of animals were compared, - those with sham/vehicle operations and those with 6-OHDA dopamine (DA) depleting lesions in -  the frontal cortex, the limbic septum, and the ventral tegmental area (VTA - A10).   Results:  1/ Lesions of the VTA resulted in increased dark-phase activity, - and a large response to an apomorphine challenge in comparison to other lesion and control groups: 2/ Septal 6-OHDA lesions did not alter locomotion: 3/ After frontal DA depletion there was a small increase of locomotion after the apomorphine challenge, that might reflect increased receptor sensitivity in cortical or sub-cortical areas: (Table 1: HPLC measures of NA, DA and DOPAC for each group in the prefrontal cortex, septum and N. accumbens)   Figure 1 illustrates the cumulative photocell counts per hour over 24 hours for the 4 groups:. Figure 2 illustrates the cumulative photocell counts every 10 minutes over 90 minutes post-apomorphine treatment - maximal at 20-30 minutes and habituating over 60 minutes (90 minutes for the VTA group): overall activity VTA >> Frontal > Septal > Controls.  Conclusions: Along with correlations found for motor activity with cortical levels of DA and NA, these results are interpreted to support a role for DA, NA and the region of the frontal cortex in modulating locomotion that is primarily mediated by mesolimbic VTA - accumbens - DA activity. 
publisher: S.Karger
date: 1986
type: Journal (Paginated)
type: PeerReviewed
format: application/pdf
identifier: http://cogprints.org/1372/2/rat-npb-86.pdf
identifier:   Oades, R.D. and Taghzouti, K. and Rivet, J-M. and Simon, H. and Le Moal, M.  (1986) Locomotor activity in relation to dopamine and noradrenaline in the nucleus accumbens, septal and frontalk areas: a 6-hydroxydopamine study.  [Journal (Paginated)]     
relation: http://cogprints.org/1372/