?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Locomotor+activity+in+relation+to+dopamine+and+noradrenaline+in+the+nucleus+accumbens%2C+septal+and+frontalk+areas%3A+a+6-hydroxydopamine+study&rft.creator=Oades%2C+R.D.&rft.creator=Taghzouti%2C+K.&rft.creator=Rivet%2C+J-M.&rft.creator=Simon%2C+H.&rft.creator=Le+Moal%2C+M.&rft.subject=Behavioral+Neuroscience&rft.subject=Behavioral+Biology&rft.subject=Neuropharmacology&rft.subject=Psychobiology&rft.description=The+Study+and+the+Method%3A+%0AThe+locomotor+activity+of+adult+male+Sprague-Dawley+was+automatically+recorded+in+a+circular+corridor+-+circadian+changes+are+described+as+well+as+the+response+to+the+novel+situation+and+its+habituation+over+three+hours.%0AFour+groups+of+animals+were+compared%2C+-+those+with+sham%2Fvehicle+operations+and+those+with+6-OHDA+dopamine+(DA)+depleting+lesions+in+-+%0Athe+frontal+cortex%2C%0Athe+limbic+septum%2C+and%0Athe+ventral+tegmental+area+(VTA+-+A10).+%0A%0AResults%3A+%0A1%2F+Lesions+of+the+VTA+resulted+in+increased+dark-phase+activity%2C+-+and+a+large+response+to+an+apomorphine+challenge+in+comparison+to+other+lesion+and+control+groups%3A%0A2%2F+Septal+6-OHDA+lesions+did+not+alter+locomotion%3A%0A3%2F+After+frontal+DA+depletion+there+was+a+small+increase+of+locomotion+after+the+apomorphine+challenge%2C+that+might+reflect+increased+receptor+sensitivity+in+cortical+or+sub-cortical+areas%3A%0A(Table+1%3A+HPLC+measures+of+NA%2C+DA+and+DOPAC+for+each+group+in+the+prefrontal+cortex%2C+septum+and+N.+accumbens)+%0A%0AFigure+1+illustrates+the+cumulative+photocell+counts+per+hour+over+24+hours+for+the+4+groups%3A.%0AFigure+2+illustrates+the+cumulative+photocell+counts+every+10+minutes+over+90+minutes+post-apomorphine+treatment+-+maximal+at+20-30+minutes+and+habituating+over+60+minutes+(90+minutes+for+the+VTA+group)%3A+overall+activity+VTA+%3E%3E+Frontal+%3E+Septal+%3E+Controls.%0A%0AConclusions%3A%0AAlong+with+correlations+found+for+motor+activity+with+cortical+levels+of+DA+and+NA%2C+these+results+are+interpreted+to+support+a+role+for+DA%2C+NA+and+the+region+of+the+frontal+cortex+in+modulating+locomotion+that+is+primarily+mediated+by+mesolimbic+VTA+-+accumbens+-+DA+activity.%0A&rft.publisher=S.Karger&rft.date=1986&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F1372%2F2%2Frat-npb-86.pdf&rft.identifier=++Oades%2C+R.D.+and+Taghzouti%2C+K.+and+Rivet%2C+J-M.+and+Simon%2C+H.+and+Le+Moal%2C+M.++(1986)+Locomotor+activity+in+relation+to+dopamine+and+noradrenaline+in+the+nucleus+accumbens%2C+septal+and+frontalk+areas%3A+a+6-hydroxydopamine+study.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F1372%2F