?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=The+evolutionary+origin+of+the+mammalian+isocortex%3A+insights+from+molecular+developmental+biology&rft.creator=Aboitiz%2C+Francisco&rft.creator=Morales%2C+Daniver&rft.creator=Montiel%2C+Juan.&rft.subject=Evolution&rft.subject=Neuroanatomy&rft.description=The+isocortex+is+a+distinctive+feature+of+the+mammalian+brain%2C+which+has+no+clear+counterpart+in+the+cerebral+hemispheres+of+other+amniotes.+Historically%2C+there+have+been+long-standing+controversies+regarding+possible+homologues+of+this+structure+in+reptiles+and+birds.+In+these+vertebrate+classes%2C+a+structure+denominated+dorsal+ventricular+ridge+develops+in+the+lateral+aspect+of+the+hemisphere+and%2C+like+the+mammalian+isocortex%2C+receives+ascending+auditory+and+visual+tectofugal+projections.+On+these+grounds%2C+it+has+been+postulated+that+part+of+the+dorsal+ventricular+ridge+is+homologue+to+part+of+the+mammalian+isocortex+(i.e.+the+auditory+and+the+extrastriate+visual+cortices).+Dissenting+views+have+claimed+that+the+dorsal+ventricular+ridge+originates+from+a+topographically+different+part+of+the+hemisphere+than+the+isocortex%2C+and+therefore+there+is+no+embryonic+similarity+between+these+two+structures.+Furthermore%2C+recent+evidence+on+the+expression+patterns+of+regulatory+genes+strongly+suggests+that+a+large+part+of+the+dorsal+ventricular+ridge+arises+from+a+region+denominated+the+intermediate+territory+or+ventral+pallium%2C+which+in+mammals+gives+rise+to+parts+of+the+amygdalar+complex+among+other+structures.+Considering+that+embryological+criteria+are+in+some+cases+more+reliable+to+determine+homology+than+comparisons+of+adult+states%2C+we+are+inclined+for+the+developmental+approach%2C+which+prescribes+non-homology+between+the+isocortex+and+the+dorsal+ventricular+ridge.+Additionally%2C+we+suggest+a+scenario+for+the+origin+of+the+isocortex+as+an+expansion+of+the+reptilian+dorsal+cortex%2C+which+is+consistent+with+current+evidence.&rft.date=2000-01&rft.type=Preprint&rft.type=NonPeerReviewed&rft.format=text%2Fhtml&rft.identifier=http%3A%2F%2Fcogprints.org%2F132%2F1%2FBBS12.html&rft.identifier=++Aboitiz%2C+Francisco+and+Morales%2C+Daniver+and+Montiel%2C+Juan.++(2000)+The+evolutionary+origin+of+the+mammalian+isocortex%3A+insights+from+molecular+developmental+biology.++%5BPreprint%5D++++(Unpublished)++&rft.relation=http%3A%2F%2Fcogprints.org%2F132%2F