?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Effect+of+partial+pancreatectomy+on+diabetic+status+in+BALB%2Fc+mice.&rft.creator=Hardikar%2C+AA&rft.creator=Karandikar%2C+MS&rft.creator=Bhonde%2C+RR&rft.subject=Animal+Behavior&rft.description=Pancreatic+regeneration+after+pancreatectomy+has+been+well+documented+in+animal+models.+However%2C+the+phenomenon+of+pancreatic+regeneration+in+diabetes+has+not+been+exploited+as+yet.+We+report+here+the+restoration+of+euglycaemic+status+in+streptozotocin+(STZ)-induced+diabetic+BALB%2Fc+mice%2C+after+50%25+pancreatectomy.+We+observed+that%2C+after+pancreatectomy%2C+STZ-diabetic+mice+showed+a+rapid+improvement+in+glycaemic+status%2C+starting+from+the+8th+postoperative+day%2C+and+remained+normoglycaemic+throughout+a+90-day+follow-up+study.+STZ-induced+diabetic+and+control+non-diabetic+BALB%2Fc+mice+underwent+pancreatectomy+and+were+monitored+regularly+for+changes+in+body+weight%2C+plasma+glucose+and+serum+insulin+concentrations+and+histological+status+of+the+pancreas.+All+the+pancreatectomised+animals+showed+euglycaemic+status+from+about+20+days+after+operation%2C+whereas+a+majority+(around+70%25)+of+the+diabetic%2C+sham-operated+animals+died+of+sustained+hyperglycaemia+by+20-30+days+after+operation.+Examination+of+the+regenerating+pancreas+indicated+nesidioblastotic+activity+and+supported+the+theory+of+a+ductal+origin+of+islet+stem+cells.+Islets+isolated+from+the+regenerating+pancreas+showed+a+progressive+increase+in+islet+area+(1227.9%2B%2F-173.2+micrometer(2)+on+day+5+compared+with+2473.8%2B%2F-242.0+micrometer(2)+by+day+20).+The+increment+in+insulin+concentrations+and+subsequent+decrement+in+glycaemia+of+the+diabetic+pancreatectomised+animals+indicate+islet+neogenesis+occurring+after+the+operative+insult%2C+leading+to+a+normoglycaemic+status%2C+probably+recapitulating+ontogeny.+We+have+shown+that+induction+of+a+regenerative+stimulus+(pancreatectomy)+in+conditions+of+STZ-induced+diabetes+may+trigger+pancreatic+regenerative+processes%2C+thereby+restoring+a+functional+pancreas%2C+in+STZ-diabetic+mice.%0A&rft.date=1999-08&rft.type=Journal+(On-line%2FUnpaginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F1311%2F3%2F1620189.pdf&rft.identifier=++Hardikar%2C+AA+and+Karandikar%2C+MS+and+Bhonde%2C+RR++(1999)+Effect+of+partial+pancreatectomy+on+diabetic+status+in+BALB%2Fc+mice.++%5BJournal+(On-line%2FUnpaginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F1311%2F