?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Event-related+potentials+and+monoamines+in+autistic+children+on+a+clinical+trial+of+fenfluramine&rft.creator=Oades%2C+R.D.&rft.creator=Stern%2C+L.M.&rft.creator=Walker%2C+M.K.&rft.creator=Clark%2C+C.R.&rft.creator=Kapoor%2C+V.&rft.subject=Neuropharmacology&rft.subject=Neurophysiology&rft.subject=Neuropsychiatry&rft.description=Introduction%3A+As+autistic+persons+have+problems+with+selecting+and+encoding+meaningful+stimuli+and+multi-centre+studies+(Ritvo+et+al.%2C+1983%2C+1986)+had+reported+mild+behavioural+improvements+following+treatment+with+fenfluramine%2C+event-related+potential+(ERP)+stages+of+information+processing+were+studied+in+childhood+autism+as+part+of+a+double+blind+crossover+study+of+the+efficacy+of+dl+fenfluramine.+.+%0A%0AMethods%3A+Acceptable+recordings+were+derived+from+midline+and+4+lateral+sites+on+the+scalp+of+7+from+14+young+persons+with+autism+who+understood+the+task+(6+male%2C+1+female+5.8-17.7+years-of-age).+A+three-tone+oddball+paradigm+was+presented+in+a+passive+and+active-task+form+(72%25+at+1+kHz%2C+14%25+at+0.5+kHz+and+14%25+at+2.0+kHz)+under+placebo+and+drug+conditions+(where+each+condition+lasted+5+months).+Eleven+patients+provided+blood+and+urine+samples+for+monoamine+analyses+in+both+conditions.%0A%0AResults%3A+%0Aa)+With+fenfluramine+treatment+blood+serotonin+decreased+and+urinary+catecholamine+levels+fell+(25-45%25%2C+but+dopamine+utilization+(HVA%2FDA)+increased+2-4-fold.+%0Ab)+Under+fenfluramine+autistic+subjects+responded+non-significantly+faster%2C+with+fewer+errors+of+omission+and+improved+%2Fdecreased+beta+criterion+(signal+detection).+%5BIQ+measures+increased+7.5+points.%5D%0Ac)+N1+amplitudes+(Fz)+decreased+and+latencies+increased+in+the+fenfluramine+condition.%0AEarly+negativity+(especially+on+the+right)+correlated+inversely+with+HVA%2FDA+actvivity.%0ASubtraction+of+the+ERPs+in+nontarget+from+target+conditions+showed+that+the+Negative+difference+(Nd)+increased+during+fenfluramine+treatment.%0Ad)+P3+amplitudes+(especially+after+the+deviants)+increased+with+fenfluramine+treatment.+But+in+the+difference+waveform+(active-minus-passive+condition)+the+P3+amplitude+was+halved.+The+distribution+of+the+P3+component+moved+rostrally+with+treatment.+%0A%0A%0AConclusions%3A+N1+and+P3+components+of+the+ERP+were+responsive+to+fenfluramine+treament.+Treatment+appears+to+have+mildly+improved+early+stimulus+processing+at+stages+represented+by+the+early+negative+components%2C+but+to+have+mildly+impaired+processing+at+the+P3-stage.+The+N1+%2F+Nd+-+related+improvement+seems+to+be+related+to+increased+dopamine+activity+(cf.+neuroleptic-like+properties+of+racemate+fenfluramine).%0A%0A&rft.publisher=Elsevier&rft.date=1990&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F1256%2F2%2FAut1990.pdf&rft.identifier=++Oades%2C+R.D.+and+Stern%2C+L.M.+and+Walker%2C+M.K.+and+Clark%2C+C.R.+and+Kapoor%2C+V.++(1990)+Event-related+potentials+and+monoamines+in+autistic+children+on+a+clinical+trial+of+fenfluramine.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F1256%2F