?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Event-related+potentials+in+autistic+and+healthy+children+on+an+auditory+choice+reaction+time+task&rft.creator=Oades%2C+R.D.&rft.creator=Walker%2C+M.K.&rft.creator=Geffen%2C+L.B.&rft.creator=Stern%2C+L.M.&rft.subject=Neuropsychology&rft.subject=Neuropsychiatry&rft.subject=Psychophysics&rft.description=Introduction%3A+Childhood+autism+can+occur+in+5+out+of+10%2C000+of+the+population.+The+condition+covers+problems+of+sensory+modulation%2C+comprehension+and+communication+as+it+relates+to+both+objects+and+people.+Of+the+stages+of+information+processing+recorded+in+auditory+event-related+potentials+(ERPs)%2C+reductions+of+N1+and+P3+amplitude+have+been+reported+in+many+situations%2C+but+an+increased+P3+response+to+non-targets+may+represent+difficulties+in+attributing+differentially+significance+to+some+but+not+all+stimuli..+%0A%0AMethods%3A+Recordings+were+derived+from+midline+and+4+lateral+sites+on+the+scalp+of+7+children+with+autism+and+7%2F13+healthy+control+children+matched+for+age+(median+139+vs.+135+months).+A+three-tone+oddball+paradigm+was+presented+in+a+passive+and+active-task+form+(72%25+at+1+kHz%2C+14%25+at+0.5+kHz+and+14%25+at+2.0+kHz)%0A%0AResults%3A+%0Aa)+Autistic+subjects+showed+twice+as+many+errors+of+omission+and+a+higher+beta+criterion+(signal+detection)+for+targets.+%0Ab)+For+autistic+subjects+N1+latencies+were+shorter+and+N1+amplitude+larger+to+deviants+(especially+nontargets).%0Ac)+However%2C+subtraction+of+the+ERPs+in+nontarget+from+target+conditions+showed+that+the+processing+negativity+(PN)+and+especially+the+Negative+difference+(Nd)+was+smaller+in+autistic+subjects.%0Ad)+In+contrast+the+P3+amplitude+(especially+after+the+target)+was+smaller+in+autistic+subjects.%0Ae)+Within+autistic+subjects+the+topography+showed+more+early+negativity+after+deviants+at+left+frontal+sites+and+more+target+induced+late+positivity+at+right+parietal+sites.+%0A%0AConclusions%3A+The+ERPs+of+autistic+children+were+more+responsive+to+stimulus+features+(high+frequency+or+deviance)+and+less+responsive+to+the+stimulus+associations+(target+features).+The+ERPs+also+provide+conflicting+signs+of+neurodevelopment%2C+--+precocious+in+the+right-hemispheric+emphasis+for+P3%2C+but+delayed+in+that+P3+was+not+maximal+at+parietal+sites.%0A%0A&rft.publisher=Elsevier&rft.date=1988&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F1255%2F2%2FAut1988.pdf&rft.identifier=++Oades%2C+R.D.+and+Walker%2C+M.K.+and+Geffen%2C+L.B.+and+Stern%2C+L.M.++(1988)+Event-related+potentials+in+autistic+and+healthy+children+on+an+auditory+choice+reaction+time+task.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F1255%2F