?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Monoamine+activity+reflected+in+urine+of+young+patients+with+obsessive+compulsive+disorder%2C+psychosis+with+and+without+reality+distortion+and+healthy+subjects%3A+an+explorative+analysis&rft.creator=Oades%2C+R.+D.&rft.creator=R%C3%B6pcke%2C+&rft.creator=Eggers%2C+&rft.subject=Neurochemistry&rft.subject=Neuropsychiatry&rft.subject=Psychobiology&rft.description=Introduction%3A+Positive+psychotic+symptoms+are+reported+to+be+associated+with+high+dopamine+(DA)%2C+negative+symptoms+with+low+DA+activity+and+serotonin+(5-HT)+activity+may+be+altered+in+obsessive-compulsive+disorder+(OCD).+%0A%0AMethod%3A+We+analysed+24h+urine+samples+in+groups+of+patients+with+OCD%2C+paranoid+and+non-paranoid+schizophrenia+and+in+healthy+controls+for+supportive+evidence.+%0A%0AResults%3A+Young+unmedicated+OCD+subjects+excreted+more+adrenaline+(AD)+and+homovanillic+acid+(HVA)+and+showed+a+higher+HVA%2FMHPG+metabolite+ratio+and+metabolic+rate+than+healthy+controls.+Independent+of+general+metabolic+rate+OCD+patients+showed+higher+HVA+concentrations+which+suggests+that+the+relative+activity+of+catecholamine+systems+in+OCD+(HVA%2FMHPG)+is+due+more+to+high+DA+than+to+low+noradrenergic+(NA)+activity.+Concentrations+of+5-HT+were+also+high+in+OCD+patients.+In+psychotic+patients+low+levels+of+DA%2C+HVA%2C+NA+and+MHPG+probably+resulted+from+neuroleptic+medication.+%0A%0AConclusions%3A+1.+Patients+diagnosed+with+paranoid+psychosis+showed+higher+DA+utilization+than+controls+and+those+with+few+paranoid+symptoms+showed+high+5-HT+utilization.+2.+These+results+support+studies+suggesting+that+paranoid+psychosis+is+associated+more+with+increased+DA+activity+(discussed+in+the+context+of+neuroleptic+reactivity)%2C+that+non-paranoid+forms+are+associated+more+with+increased+5-HT+activity+and+that+OCD+patients+are+unusually+aroused+with+high+levels+of+Adrenaline%2C+5-HT+and+HVA.+%0A++&rft.publisher=Springer-Verlag&rft.date=1994&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F1227%2F2%2Fjnt-1994.pdf&rft.identifier=++Oades%2C+R.+D.+and+R%C3%B6pcke%2C++and+Eggers%2C+++(1994)+Monoamine+activity+reflected+in+urine+of+young+patients+with+obsessive+compulsive+disorder%2C+psychosis+with+and+without+reality+distortion+and+healthy+subjects%3A+an+explorative+analysis.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F1227%2F