?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Event-related+potentials+during+an+auditory+discrimination+with+prepulse+inhibition+in+patients+with+schizophrenia%2C+obsessive-compulsive+disorder+and+healthy+subjects&rft.creator=Schall%2C+Ulrich&rft.creator=Schoen%2C+Anja&rft.creator=Zerbin%2C+Dieter&rft.creator=Eggers%2C+Christian&rft.creator=Oades%2C+Robert+D.&rft.subject=Neurophysiology&rft.subject=Neuropsychiatry&rft.subject=Perceptual+Cognitive+Psychology&rft.description=Introduction%3A+Prepulse+inhibition+(PPI)+is+a+measure+of+the+influence+of+a+stimulus+(S1)+on+the+response+elicited+by+a+second+stimulus+(S2)+occurring+shortly+afterwards.+Most+S1%2FS2+measures+of+gating+have+used+behavioral+startle+and+the+P50+event-related+potential+(ERP)+amplitudes+to+detect+PPI+in+a+simple+paired+stimulus+paradigm.+%0A%0AAims%3A+Here+we+report+on+two+behavioral+(EOG+and+reaction+time%2C+RT)+and+5+ERP+measures+of+PPI+where+S2+was+the+target+or+standard+in+an+oddball+discrimination.+Subjects+were+21+healthy+controls+(CON)%2C+11+obsessive-compulsive+(OCD)+and+9+schizophrenic+patients+(SCH).++%0A%0AResults%3A+The+prepulse+100ms+before+S2+induced+fewer+omission+errors+and+longer+RTs+compared+to+a+500ms+S1-S2+interval+in+all+subjects.+PPI+was+also+evident+in+EOG%2C+P50%2C+N1%2C+P3+but+not+P2+or+N2+amplitudes+of+CON+subjects.+SCH+patients+showed+attenuation+of+PPI+on+the+same+measures.+OCD+patients+were+characterized+only+by+their+slow+RT+and+a+marginal+attenuation+of+EOG-PPI.+%0A%0ADiscussion%3A+A+correlational+analysis+implied+separate+relationships+of+ERP+indices+of+PPI+to+the+cognitive+and+psychomotor+consequences+of+the+prepulse+on+behavioral+and+discrimination+responses.+However+SCH+patients+showed+a+general+rather+than+a+specific+impairment+of+these+indices.+%0A%0A&rft.publisher=Gordon+and+Breach&rft.date=1996&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F1181%2F2%2FInt.J.Neurosci.96.pdf&rft.identifier=++Schall%2C+Ulrich+and+Schoen%2C+Anja+and+Zerbin%2C+Dieter+and+Eggers%2C+Christian+and+Oades%2C+Robert+D.++(1996)+Event-related+potentials+during+an+auditory+discrimination+with+prepulse+inhibition+in+patients+with+schizophrenia%2C+obsessive-compulsive+disorder+and+healthy+subjects.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F1181%2F