?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Conditioned+blocking+in+patients+with+paranoid%2C+non-paranoid+psychosis+or+obsessive+compulsive+disorder%3A+associations+with+symptoms%2C+personality+and+monoamine+metabolism&rft.creator=OADES%2C+R.+D.&rft.creator=ZIMMERMANN%2C+B.&rft.creator=EGGERS%2C+C.&rft.subject=Neurochemistry&rft.subject=Neuropsychiatry&rft.description=Introduction%3A+Conditioned+blocking+(CB)+refers+to+a+delay+in+learning+that+a+new+stimulus%2C+added+during+learning%2C+has+the+same+consequences+as+the+conditioned+stimulus+already+present.+In+animals+such+%22learned+inattention%22+depends+on+monoaminergic+and+limbic+function+and%2C+thus%2C+CB+performance+should+be+informative+on+selective+information+processing+impairments+found+in+subgroups+of+psychotic+patients.+Attenuated+CB+in+acute+schizophrenia+has+been+reported+to+normalize+rapidly.%0A%0AMethod%3A+This+study+examines+in+young+patients+the+specificity+of+CB+performance+to+illness%2C+and+its+associations+with+symptoms%2C+personality+traits+and+monoaminergic+metabolic+status.%0A%0AResults%3A+Performance%3A+CB+was+attenuated+in+psychotic+patients+with+nonparanoid+symptoms+(NP%3A+n%3D12%2C+mean+age+17+years)+with+respect+to+obsessive+compulsive+(OCD%3A+n%3D13%2C+mean+age+16+years)+and+healthy+subjects+(CON%3B+n%3D29%2C+mean+age+18+years)%2C+but+only+a+transient+attenuation+was+observed+in+paranoid+hallucinatory+patients+(PH%3A+n%3D14%2C+mean+age+19+years).+The+severity+of+negative+symptoms+in+psychosis+and+specific+negative%2Fpositive+symptoms+in+the+NP%2FPH+groups+were+associated+with+reduced+CB.+Outgoing+personality+traits+in+CON+and+OCD+subjects+correlated+with+CB.+In+NP+patients+attenuated+CB+was+associated+with+increasing+neurotic+lability.+In+PH+patients+CB+correlated+positively+with+%22manic%22+but+negatively+with+psychotic+or+neurotic+scores.+Monoamines%3A+Increased+dopamine+activity+(24h+urine+samples)+correlated+positively+with+CB%2C+but+relative+increases+of+noradrenaline+metabolism+in+NP+and+serotonin+metabolism+in+OCD+patients+interfered.%0A%0AConclusions%3A+Marked+psychotic+or+neurotic+traits+and+some+negative+symptom+states+were+associated+with+reduced+CB.+The+particular+selective+processing+problems+of+NP+patients+may+reflect+inappropriate+NA+activity.+%0A%0A&rft.publisher=Elsevier&rft.date=1996&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F1166%2F2%2Fj.Psychia.research.pdf&rft.identifier=++OADES%2C+R.+D.+and+ZIMMERMANN%2C+B.+and+EGGERS%2C+C.++(1996)+Conditioned+blocking+in+patients+with+paranoid%2C+non-paranoid+psychosis+or+obsessive+compulsive+disorder%3A+associations+with+symptoms%2C+personality+and+monoamine+metabolism.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F1166%2F