?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Submicrosecond+pacemaker+precision+is+behaviorally+modulated%3A+The+gymnotiform+electromotor+pathway&rft.creator=Moortgat%2C+Katherine+T.&rft.creator=Keller%2C+Clifford+H.&rft.creator=Bullock%2C+Theodore+H.&rft.creator=Sejnowski%2C+Terrence+J.&rft.subject=Behavioral+Neuroscience&rft.subject=Brain+Imaging&rft.subject=Neurochemistry&rft.subject=Neural+Modelling&rft.subject=Neurology&rft.subject=Neurology&rft.subject=Neuropharmacology&rft.subject=Neurophysiology&rft.description=What+are+the+limits+and+modulators+of+neural+precision%3F+We+address+this+question+in+the+most+regular+biological+oscillator+known%2C+the+electric+organ+command+in+the+brainstem+of+wave-type+electric+fish.+The+oscillating+electric+organ+discharge+(EOD)%2C+used+in+electrolocation+and+communication%2C+has+high+regularity+measured+by+a+low+coefficient+of+variation+(CV+as+low+as+2+x+10-4)+in+five+species+from+three+families+ranging+in+mean+EOD+from+70+to+1250+Hz.+Intracellular+recording+in+the+nucleus+(Pn)+pacing+EODs+reveals+that+individual+Pn+neurons+also+display+an+extremely+low+CV.+While+the+CV+can+remain+at+its+minimum+for+hours%2C+it+varies+with+novel+environmental+conditions%2C+during+communication%2C+and+spontaneously.+Spontaneous+changes+occur+as+abrupt+steps+(250+msec)%2C+oscillations+(35+Hz)%2C+or+slow+ramps+(1030+sec).+Several+findings+suggest+that+these+changes+are+under+active+control+and+depend+on+behavioral+state.+Mean+EOD+frequency+and+CV+can+change+independently.+CV+often+decreases+in+response+to+stimuli.+Lesions+of+one+of+the+two+inputs+to+the+Pn+had+more+influence+on+CV+than+lesions+of+the+other+input&rft.date=1998-04&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=text%2Fhtml&rft.identifier=http%3A%2F%2Fcogprints.org%2F105%2F1%2Fktm-ms1-31.htm&rft.identifier=++Moortgat%2C+Katherine+T.+and+Keller%2C+Clifford+H.+and+Bullock%2C+Theodore+H.+and+Sejnowski%2C+Terrence+J.++(1998)+Submicrosecond+pacemaker+precision+is+behaviorally+modulated%3A+The+gymnotiform+electromotor+pathway.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F105%2F