Reproductive Wastage in Recurrent Partial Hydatidiform Mole: A Clinical Dilemma.

Shakuntala, PN and Ashmita, D and Shubha, RR and Usha, R (2013) Reproductive Wastage in Recurrent Partial Hydatidiform Mole: A Clinical Dilemma. [Journal (On-line/Unpaginated)]

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Recurrent partial Hydatidiform mole is an extremely rare clinical entity which represent a part of the gestational trophoblatic neoplasia spectrum. Since the first case was reported by Honore. LM in 1987 about eight cases of , recurrent partial moles have been reported in the English medical literature. Present two cases are the 9th and 10th case with recurrent partial moles to be described. We have discussed the aetiology, environmental factors, dietary habits , clinicopathologic features, the clinical dielemmas faced by us while counselling, follow up and pregnancy outcome in women presenting with two and three recurrent partial moles respectively. We have also reviewed the literature.

Item Type:Journal (On-line/Unpaginated)
Keywords:Recurrent Partial Hydatidiform moles; Dietary habits; Pregnancy outcome
Subjects:JOURNALS > Online Journal of Health and Allied Sciences
ID Code:8943
Deposited By: Kakkilaya Bevinje, Dr. Srinivas
Deposited On:04 May 2013 23:09
Last Modified:04 May 2013 23:09

References in Article

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1. Palmer JR. Advances in the epidemiology of gestational trophoblastic disease. J Reprod Med 1994;39:155–161.

2. Al-Hussainia TK, Abd El Aala DM , Van den Veyverb IB. Recurrent pregnancy loss due to familial and non-familial habitual molar pregnancy. Int J Gynecol and Obstet 2003;83:179–186.

3. Honoré LH. Recurrent partial hydatidiform mole: Report of a case. Am J Obstet Gynecol. Apr 1987;156(4):922-924.

4. Honore´ L, Lin EC, Morrish DW. Recurrent partial mole. Am J Obstet Gynecol 1988;158:442.

5. Rice LW, Lage JM, Berkowitz RS, Goldstein DP, Bernstein MR. Repetitive completed and partial hydatidiform mole. Obstet Gynecol 1989;74:217–219.

6. Narayan H, Mansour P, McDougall WW. Recurrent consecutive partial molar pregnancy. Gynecol Oncol 1992;46:122–127.

7. Helwani MN, Seoud M, Zahed L, Zaatari G, Khalil A, Slim R. A familial case of recurrent hydatidiform molar pregnancies with biparental genomic contribution. Hum Genet 1999;105:112–115.

8. Koc S, Ozdegirmenci O, Tulunay G, Ozgul N, Kose M.F. & Bulbul D. Recurrent partial hydatidiform mole. A report of a patient with three consecutive molar pregnancies. Int J Gynecol Cancer 2006;16: 884–943 .

9. Slim R, Ao A, Surti U, Zhang L, Hoffner L, Arseneau J, Cheung A, Chebaro W, Wischmeijer A. Recurrent triploid and dispermic conceptions in patients with NLRP7 mutations. Placenta. 2011 May;32(5):409-412. doi: 10.1016/j.placenta.2011.02.001. Epub 2011 Mar 21.

10. Dixon PH, Trongwongsa P, Abu-Hayyah S, Ng SH et al. Mutations in NLRP7 are associated with diploid biparental hydatidiform moles, but not androgenetic complete moles. J Med Genet. 2012 Mar;49(3):206-211. doi: 10.1136/jmedgenet-2011-100602. Epub 2012 Feb

11. Sebire NJ, Fisher RA, Foskett M, Rees H, Seckl MJ, Newlands ES. Risk of recurrent hydatidiform mole and subsequent pregnancy outcome following complete or partial hydatidiform molar pregnancy. BJOG 2003;110:22–26.

12. Berkowitz RS, Goldstein DP. Gestational trophoblastic diseases. In Hoskins WJ, Perez CA, Young RC, Barakat R, Markman R, Randall M, eds. Principles and practice of gynecologic oncology. 4th edn. Lippincott Williams and Wilkins. 2005. pp1055–1076.

13. Reubinoff BE, Lewin A, Verner M, Safran A, Schenker JG, Abeliovich D. Intracytoplasmic sperm injection combined with preimplantation genetic diagnosis for the prevention of recurrent gestational trophoblastic disease.Hum Reprod 1997;12(4):805–808.

14. Goto S, Yamada A, Ishizuka T, Tomoda Y. Development of Postmolar Trophoblastic Disease after Partial Molar Pregnancy. Gynecologic Oncology.February 1993;48(2):165–170.

15. Paradinas FJ, Browne P, Fisher RA, Foskett M, Bagshawe KD, Newlands E. A clinical, histopathological and flow cytometric study of 149 complete moles, 146 partial moles and 107 non-molar hydropic abortions.Histopathology. February 1996;28(2):101–109.

16. Hancock BW, Nazir K, Everard JE. Persistent gestational trophoblastic neoplasia after partial hydatidiform mole incidence and outcome. J Reprod Med. 2006 Oct;51(10):764-766.

17. Wielsma S, Kerkmeijer L, Bekkers R, Pyman J, Tan J, Quinn M. Persistent trophoblast disease following partial molar pregnancy. Aust N Z J Obstet Gynaecol. April 2006;46(2):119–123.


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