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Oncogenomics and Cancer Interactomics

Baianu, Prof. Dr I.C. (2010) Oncogenomics and Cancer Interactomics. [Book Chapter] (In Press)

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Abstract

An overview of translational, human oncogenomics, transcriptomics and cancer interactomic networks is presented together with basic concepts and potential, new applications to Oncology and Integrative Cancer Biology. Novel translational oncogenomics research is rapidly expanding through the application of advanced technology, research findings and computational tools/models to both pharmaceutical and clinical problems. A self-contained presentation is adopted that covers both fundamental concepts and the most recent biomedical, as well as clinical, applications. Sample analyses in recent clinical studies have shown that gene expression data can be employed to distinguish between tumor types as well as to predict outcomes. Potentially important applications of such results are individualized human cancer therapies or, in general, ‘personalized medicine’. Several cancer detection techniques are currently under development both in the direction of improved detection sensitivity and increased time resolution of cellular events, with the limits of single molecule detection and picosecond time resolution already reached. The urgency for the complete mapping of a human cancer interactome with the help of such novel, high-efficiency / low-cost and ultra-sensitive techniques is also pointed out.

Item Type:Book Chapter
Additional Information:To be published in ``Bioinformatics" in 2011
Keywords:signalling pathways, interactomics, genomic techniques, pharmaceutical and clinical aspects of oncogenomics
Subjects:Biology > Theoretical Biology
Psychology > Clinical Psychology
Computer Science > Complexity Theory
Computer Science > Human Computer Interaction
Computer Science > Dynamical Systems
Neuroscience > Neurogenetics
ID Code:7756
Deposited By: Baianu, Professor I. C.
Deposited On:16 Dec 2011 00:59
Last Modified:16 Dec 2011 00:59

References in Article

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