Role of immunoturbidimetric plasma fibrin D-dimer test in patients with coronary artery disease as well as ischemic heart disease in emergency medicine

Ajay K. Singh , Vikas Gupta, Neelima Singh, Sanjeev K. Singh , Nivedita Singh, Arun Raiza, Harshverdhan Singh , Int J Cur Biomed Phar Res. (2011) Role of immunoturbidimetric plasma fibrin D-dimer test in patients with coronary artery disease as well as ischemic heart disease in emergency medicine. [Journal (Paginated)]

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The aim of the present was to assess the value of the ELISA D-dimer (hemostatic marker) assay in patients with coronary artery disease as well as ischemic heart disease presenting to the emergency department with chest pain syndrome. Methods: We measured levels of D-dimers (µg/ml by immunoturbidimetric assay) in 120 patients with angiographically proved CAD, consecutive outpatients with chest pain, arterial fibrillation, acute coronary syndromes and 240 age and sex matched healthy controls. Demographic characteristics were assessed by a standardized questionnaire, and a complete lipid profile was performed for all subjects. In addition to this inflammatory marker C- reactive protein was also measured. Result: The distribution of D-dimer levels skewed to the right, and plasma mean levels were higher in cases than in control (mean: 2.51±3.60 vs .41±.59 µg/ml; p<0.001). In contrast, correlation of D-dimer was found with C-reactive protein (p<0.001) and is higher in cases than controls. Conclusion: Plasma D-dimer levels are strongly and independently associated with the presence of CAD in patients with stable angina. These results support the concept of a contribution of intravascular fibrin to atherothrombogenesis.

Item Type:Journal (Paginated)
Keywords:D-dimer, Coronary artery disease, Immunoturbidimetric method, C-reactive protein, Lipid profile.
ID Code:7329
Deposited By:CurrentSciDirect Publications, International Journal of Current Biomedical and Pharmaceutical Research (IJCBPR)
Deposited On:02 May 2011 16:51
Last Modified:02 May 2011 16:51

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