Cogprints

Antioxidant activity of aqueous extract of Monascus fermented Indian variety of rice in high cholesterol diet fed-Streptozotocin diabetic rats, an in vivo study

Rajasekaran. A, Kalaivani. M., Int J Cur Sci Res. (2011) Antioxidant activity of aqueous extract of Monascus fermented Indian variety of rice in high cholesterol diet fed-Streptozotocin diabetic rats, an in vivo study. [Journal (Paginated)]

Full text available as:

[img]
Preview
PDF (Antioxidant activity of aqueous extract of Monascus fermented Indian variety of rice in high cholesterol diet fed-Streptozotocin diabetic rats, an in vivo study) - Published Version
Available under License Creative Commons Attribution No Derivatives.

512Kb

Abstract

The present study was designed to investigate antioxidant activity of aqueous extract of Monascus fermented Indian variety of rice in high cholesterol diet fed- streptozotocin (STZ) induced diabetic rats.The Indian variety rice IR-532-E-576 was fermented with Monascus purpureus for 10 days and sterilized. High cholesterol fed-STZ-induced diabetic rats received aqueous extract of Monascus fermented Indian variety of rice at the concentration of 1.2 g / Kg of bw and 2.4 g / Kg bw daily for 30 days. The oxidative parameters like lipid peroxidation (LPO), reduced glutathione (GSH), superoxide dismutase (SOD) and catalase activities were assessed.High cholesterol diet and STZ increased the level of LPO and reduced the level of SOD, GSH and catalase, where as on administration of aqueous extract of Monascus fermented Indian variety of rice reduced the level of LPO to almost normal and increased the levels of GSH, SOD and catalase dose dependently.The present study concluded that consumption of Monascus fermented rice can be good dietary supplement for diabetes and hyperlipidemia.

Item Type:Journal (Paginated)
Keywords:Monascus; fermentation; diabetic; anti-oxidant.
Subjects:JOURNALS
ID Code:7306
Deposited By:CurrentSciDirect Publications, International Journal of Current Scientific Research (IJCSR)
Deposited On:02 May 2011 16:53
Last Modified:02 May 2011 16:53

References in Article

Select the SEEK icon to attempt to find the referenced article. If it does not appear to be in cogprints you will be forwarded to the paracite service. Poorly formated references will probably not work.

[1] Anderson D, Phillips BJ, Tian-Wei YU, Edwards AJ, Ayesh R, Butterworth KR. Effects of vitamin C supplementation in human volunteers with a range of cholesterol levels on biomarkers of oxygen radical-generated damage. Pure Appl Chem. 2000; 72:973-83.

[2] Rang HP, Dale MM, Ritter JM, Flower RJ. In:Pharmacology. Elsevier Churchil Living stone, New Delhi. 2003;385-92.

[3] Ghiselli A, Laurenti O, De Mattia G, Maiani G, Ferro-Luzzi A. Salicylate hydroxylation as an early marker of invivo oxidative stress in diabetic patients. Free Radical Biology and Medicine. 1992;13:621-626.

[4] Gopaul NK, Anggard EE, Mallet AI, Betteridge DJ, Wolff SP, Nourooz Zadeh J. Plasma 8 epi-PGF2 alpha levels are elevated in individuals with non-insulin dependent diadetes mellitus. FEBS Letter.1995; 368:225-229.

[5] Nourooz Zadeh J, Tajaddini Sarmadi, Mc Carthy S, Beteridge DJ, Wolf SP. Elevated levels of authentic plasma hydroperoxides in NIDDM. Diabetes. 1995;44:1054-1058.

[6] Rehman,A.,Nourooz-Zadeh J, Moller W, Tritschler H, Pereira P, Halliwell B. Increased oxidative damage to all DNA bases in patients with type 2 diabetes mellitus. FEBS Letter.1999; 448:120-122.

[7] Shih PT, Elices MJ, Fang ZT, Ugarova TP, Strahl D, Territo MC, Frank JS, Kovach NL, Cabans C, Berliner JA, Vora DK. Minimally modified low density lipoprotein induces monocyte adhesion to endothelial connecting segment by activating B1- integrin. Journal of Clinical Investigation.1999; 103: 613-625.

[8] Li Yang, Yong Hui Shi, Gang Hao, Wu Li, Guo-Wei Le. Increasing Oxidative Stress with Progressive Hyperlipidemia in Human: Relation between Malondialdehyde and Atherogenic Index. J Clin Biochem Nutr. 2008;43:154-158.

[9] Minhajuddin M. Hypolipidemic and antioxidant properties of tocotrienol rich fraction isolated from rice bran oil in experimentally induced hyperlipidemic rats. Food Chem. Toxicol. 2005; 43:747–753.

[10] Yang R. Effect of antioxidant capacity on blood lipid metabolism and lipoprotein lipase activity of rats fed a high-fat diet. Nutrition. 2006; 22:1185–1191.

[11] Heber D, Yip I, Ashley JM, Elashoff DA, Elashoff RM, Go VL. Cholesterol- lowering effects of a proprietary Chinese red yeast rice dietary supplement. American Journal of Clinical Nutrition. 1999; 69:231-236.

[12] Ozlem Erdogul, Sebileazirak. Review of the studies on red yeast rice(Monasccus purpureus).Turkish electronic journal of biotechnology.2004;2:37-49.

[13] Ricky WK, Bakr R. Chinese red yeast rice (Monascus pupureus fermented-rice) promotes bone formation. Chinese Medicine.2008; 3:4.

[14] Taeil Jeon, Seong Gu Hwang, Shizuka Hirai, Tohru Matsui, Hideo Yano, Teruo Kawada, Beoung Ou Lim, Dong Ki Park. Red yeast rice extracts suppress adipogenesis by down- regulating adipogenic transcription factors and gene expression in 3T3-L1 cells. Life Sciences.2004; 75: 3195-203.

[15] Stocks J, Dormandy TL. Autooxidation of human red cell lipids induced by hydrogen peroxide. Br J Hematol. 1971; 20: 95-111.

[16] Joharapurkar AA, Zambad SP, Wanjari MM, Umathe SN. In vivo evaluation of antioxidant activity of alcoholic extract of Rubia cordifolia linn. and its influence on ethanol-induced immunosuppression. Indian Journal of Pharmacology. 2003; 35: 232-6.

[17] Kakkar P, Dos B, Viswnathan P. A modified spectrophotometric assay of superoxide dismutase.Indian J Biochem. 1984; 21: 130-2.

[18] Ellman GL. Tissue sulfhydryl group. Arch Biochem Biophys. 1959; 82: 70-77.

[19] Sinha AK. Colormetric assay of catalase. Anal Bioche.1972; 47:389-94.

[20] Karuna R, Reddy SS, Baskar R, Saralakumari D. Antioxidant potential of aqueous extract of Phyllanthus amarus in rats. Indian J Pharmacol .2009; 41:64-7.

[21] Elmali E, Atlan N, Bukan N. Effect of the sulphonylurea glibenclamide on liver and kidney antioxidant enzymes in streptozocin-induced diabetic rats. Drugs R.D.2004; 5:203-208.

[22] Rai N, Maguchi S, Fugii S. Glycation and inactivation of human Cu-Zn-superoxide dimutase,identification of the in vitro glycated sites. J.Boi.Chem. 1997; 262:16969-16972.

Metadata

Repository Staff Only: item control page