Cogprints

Should Magnesium Sulphate Prophylaxis be Used in all Cases of Severe Preeclampsia?

Bhattacharya, Sohini and Naskar, Animesh and Mondal, Sukanta and Samanta, Ajanta and Pati, Shyama Pada (2011) Should Magnesium Sulphate Prophylaxis be Used in all Cases of Severe Preeclampsia? [Journal (On-line/Unpaginated)]

Full text available as:

[img]
Preview
PDF - Published Version
Available under License Creative Commons Attribution No Derivatives.

136Kb

Abstract

A case control study, undertaken in the department of Obstetrics and Gynecology in a tertiary referral centre, was designed to administer standard dose of magnesium sulphate to 50 randomly selected severely preeclamptic women in labor (Group 1). 48 women who formed the control group did not receive the drug (Group 2). The admission – delivery interval, rate of Cesarean section showed no statistically significant difference. Four patients developed convulsions in Group 1 in contrast to twelve patients in Group 2. Efficacy of magnesium sulphate at preventing eclampsia was calculated as 68%. Mild respiratory depression occurred in two cases and oliguria in eight cases in Group 1. Both the conditions improved on suspending further doses of magnesium sulphate. No patient had post partum haemorrhage in Group 1 although 4% patients had it in Group 2. Neonatal outcome was comparable in both the groups. Hence magnesium sulphate may be regarded as a fairly safe and effective prophylactic agent for eclampsia when used in severe preeclampsia in labor

Item Type:Journal (On-line/Unpaginated)
Keywords:Preeclampsia; Prophylactic magnesium sulphate
Subjects:JOURNALS > Online Journal of Health and Allied Sciences
ID Code:7255
Deposited By:Kakkilaya Bevinje, Dr. Srinivas
Deposited On:02 May 2011 18:17
Last Modified:02 May 2011 18:17

References in Article

Select the SEEK icon to attempt to find the referenced article. If it does not appear to be in cogprints you will be forwarded to the paracite service. Poorly formated references will probably not work.

1. Anthony J, Johanson RB, Duley L. Role of magnesium sulfate in seizure prevention in patients with eclampsia and preeclampsia. Drug Saf. 1996 Sep;15(3):188-99.

2. Hall DR, Odendaal HJ, Smith M. Is the prophylactic administration of magnesium sulphate in women with preeclampsia indicated prior to labour? British Journal of Obstetrics & Gynecology. July 2000;107:903-908.

3. Lowe SA, Brown MA, Dekker GA et al. Guidelines for the management of hypertensive disorders of pregnancy 2008. Australian and New Zealand Journal of Obstetrics and Gynecology 2009;49:242-246.

4. American College of Obstetricians and Gynecologists:Management of preeclampsia. Technical Bulletin 1986;No 91.

5. Repke JT, Friedman SA, Kaplan PW. Prophylaxis of eclamptic seizures: current controversies. Clin Obstet Gynecol 1992 Jun;35(2):365-374.

6. Sibai BM. Diagnosis and management of gestational hypertension and preeclampsia. Obstetrics & Gynecology: High-risk pregnancy series: An expert’s view. Jul 2003;102(1):181-192.

7. Sibai BM. Magnesium sulfate prophylaxis in preeclampsia: Lessons learned from recent trials. Am J Obstet Gynecol. 2004 Jun;190(6):1520-6.

8. Altman D, Carroli G, Duley L et al. Magpie Trial Collaborative Group. Do women with preeclampsia, and their babies benefit from magnesium sulphate? The Magpie Trial: a randomized placebo controlled trial. Lancet. 2002 Jun;359(9321):1877-1890.

9. Simon J, Gray A, Duley L Magpie Trial Collaborative Group. Cost-effectiveness of prophylactic magnesium sulphate for 9996 women with preeclampsia from 33 contries: economic evaluation of te Magpie Trial. BJOG 2006 Feb;113(2):144-151.

10. Rozenberg P. Magnesium sulphate for the management of preeclampsia. Gynecol Obstet Fertil 2006 Jan;34(1):54-59.

11. Whitlin AG, Friedman SA, Sibai BM. The effect of magnesium sulfate therapy on the duration of labor in women with mild preeclampsia at term: a randomized, double-blind, placebo-controlled trial. Am J Obstet Gynecol. 1997 Mar;176(3):623-627.

12. Leveno KJ, Alexander JM, McIntire DD. Does magnesium sulfate given for prevention of eclampsia affect the outcome of labor? Am J Obstet Gynecol. 1998 Apr;178(4):707-712.

13. Hall DR, Odendaal HJ, Smith M. Is the prophylactic administration of magnesium sulphate in women with pre-eclampsia indicated prior to labour? BJOG 2000 Jul;107(7):903-908.

14. Azaria E, Tsatsaris V, Goffinet F et al. Magnesium sulfate in obstetrics: current data. J Gynecol Obstet Biol Reprod (Paris) 2004 Oct;33(6 Pt 1):510-517.

15. Magpie Trial Follow up Study Collaborative Group - The Magpie Trial: a randomized trial comparing magnesium sulfate with placebo for preeclampsia outcome for children at 18 months. BJOG 2007 Mar;114(3):289-299.

Metadata

Repository Staff Only: item control page